2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase Cytochrome P450
  4. AZM198

AZM198 是一种具有选择性、口服活性且不可逆的 MPO 抑制剂，IC50 为 15.0 nM。AZM198 对 CYP3A4 的 IC50 为 19 μM。AZM198 有良好的脂溶性、膜通透性、代谢稳定性、安全性和药代动力学特性。AZM198 在改善血管功能、动脉粥样硬化斑块、肺动脉高压、肾病、内脏炎性脂肪沉积、异位脂肪沉积和肝纤维化等方面均具有活性。

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AZM198 Chemical Structure

AZM198 Chemical Structure

CAS No. : 1933460-23-1

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AZM198 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZM198 is a selective, orally active, and irreversible MPO inhibitor with an IC50 of 15.0 nM. AZM198 has an IC50 of 19 μM for CYP3A4. AZM198 has favorable lipophilicity, membrane permeability, metabolic stability, safety, and pharmacokinetic properties. AZM198 exhibits activity in improving vascular function, atherosclerotic plaques, pulmonary hypertension, kidney disease, visceral inflammatory fat deposition, ectopic fat deposition, and hepatic fibrosis[1].

IC50 & Target[1]

CYP3A4

19 μM (IC50)

分子量

320.80

Formula

C14H13ClN4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZM198 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZM1981933460-23-1AZM 198AZM-198Glutathione PeroxidaseCytochrome P450CYPsHL60 cellsCaco-2 cellsBalb/c 3T3 cellsBALB/c miceratsdogsguinea pigsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-W996116
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