1. Anti-infection
  2. HIV
  3. BRD-K98645985

BRD-K98645985 是一种 BAF (mammalian SWI/SNF) 转录阻遏的抑制剂,EC50 为 ~2.37 μM。BRD-K98645985 结合 ARID1A 特异的 BAF 复合物,防止核小体定位,并有效逆转 HIV-1 潜伏期,并且无 T 细胞毒性。

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BRD-K98645985 Chemical Structure

BRD-K98645985 Chemical Structure

CAS No. : 1357647-78-9

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MCE 顾客使用本产品发表的 2 篇科研文献

查看 HIV 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity[1].

IC50 & Target[1]

BAF transcriptional repression

2.37 μM (EC50)

HIV-1

 

体外研究
(In Vitro)

BRD-K98645985 (30 μM;18 小时) 处理显示 Bmi1 增加 5 倍,Ring1 增加 2.6 倍,Fgf4 减少 3.3 倍 [1]
BRD-K98645985 处理显示 J-Lat T 细胞系模型中的浓度依赖性潜伏期逆转。BRD-K98645985 可以与其他 LRA 结合使用以提高储层靶向性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

BRD-K98645985 (30 μM;18 小时) 处理显示 Bmi1 增加 5 倍,Ring1 增加 2.6 倍,Fgf4 减少 3.3 倍 [1]
BRD-K98645985 处理显示 J-Lat T 细胞系模型中的浓度依赖性潜伏期逆转。BRD-K98645985 可以与其他 LRA 结合使用以提高储层靶向性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

573.73

Formula

C33H43N5O4

CAS 号
性状

固体

颜色

White to light brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.67%

参考文献

BRD-K98645985 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BRD-K98645985
目录号:
HY-114268
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