2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. BRD4884

BRD4884 是一种强效且可穿过血脑屏障的 HDAC 抑制剂，对 HDAC1、HDAC2 和 HDAC3 的 IC50 值分别为 29 nM、62 nM 和 1090 nM。BRD4884 可用于认知障碍的研究。

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BRD4884 Chemical Structure

BRD4884 Chemical Structure

CAS No. : 1404559-91-6

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规格 价格 是否有货 数量
500 μg ￥666
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BRD4884 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD4884 is a potent and brain-penetrant HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1090 nM for HDAC1, HDAC2, and HDAC3, respectively. BRD4884 can be used for the study of cognitive impairment[1].

IC50 & Target

HDAC1

29 nM (IC50)

HDAC2

62 nM (IC50)

HDAC3

1.09 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
0.029 μM
Compound: BRD4884
Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate
Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate
[PMID: 27377864]
Sf9 IC50
0.062 μM
Compound: BRD4884
Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay
Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptide as substrate after 60 mins by fluorescence assay
[PMID: 27377864]
体外研究
(In Vitro)

BRD4884 (10 μM，24 小时) 在小鼠原代神经元细胞培养试验中可提高 H4K12 和 H3K9 组蛋白乙酰化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4884 相关抗体:
体内研究
(In Vivo)

BRD4884 (1-10 mg/kg；腹腔注射；每日一次；持续 10 天) 可挽救 CK-p25 小鼠海马体的相关记忆缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CK-p25 mice (3 months) were induced for 6 weeks to obtain forebrain-specific expression of p25[1].
Dosage: 1 mg/kg, 10 mg/kg
Administration: i.p.; daily; for 10 days
Result: Rescued the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning.
分子量

314.35

Formula

C18H19FN2O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (190 KB)

产品使用指南 (1538 KB)
参考文献

BRD4884 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD48841404559-91-6BRD 4884BRD-4884HDACHistone deacetylasesHDAC1HDAC2and HDAC3cognitive impairmentInhibitorinhibitorinhibit

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产品名称：
BRD4884
目录号：
HY-102083
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