2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. Camostat

Camostat 是一种具有口服活性的胰蛋白酶抑制剂。Camostat 可减少大鼠重复施用超氧化物歧化酶抑制剂诱导的胰腺纤维化，减少胰腺星状细胞 (PSC) 的增殖活化。

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Camostat Chemical Structure

Camostat Chemical Structure

CAS No. : 59721-28-7

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥272
In-stock
5 mg ￥248
In-stock
10 mg ￥400
In-stock
25 mg ￥654
In-stock
50 mg ￥900
In-stock
100 mg ￥1300
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Camostat:

Camostat 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 35 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Calu-3 CC50
200 μM
Compound: Camostat
Cytotoxicity against human Calu-3 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay
Cytotoxicity against human Calu-3 cells infected with SARS-COV-2 by celltiter-glo luminescent cell viability assay
[PMID: 34273661]
HEK293 IC50
12.7 μM
Compound: camostat
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
[PMID: 23241029]
HEK293 IC50
16.5 μM
Compound: camostat
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
[PMID: 23241029]
HEK293 IC50
2.9 μM
Compound: camostat
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
[PMID: 23241029]
Sf9 IC50
32 μM
Compound: 7
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to cromogenic substrate addition by spectrophotometry
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to cromogenic substrate addition by spectrophotometry
[PMID: 25882520]
Vero IC50
> 50 μM
Compound: Camostat
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
10.1101/2020.03.20.999730
Vero CC50
> 50 μM
Compound: Camostat
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
10.1101/2020.03.20.999730
Clinical Trial
分子量

398.41

Formula

C20H22N4O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 175 mg/mL (439.25 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5100 mL 12.5499 mL 25.0998 mL
5 mM 0.5020 mL 2.5100 mL 5.0200 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Camostat 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5100 mL 12.5499 mL 25.0998 mL 62.7494 mL
5 mM 0.5020 mL 2.5100 mL 5.0200 mL 12.5499 mL
10 mM 0.2510 mL 1.2550 mL 2.5100 mL 6.2749 mL
15 mM 0.1673 mL 0.8367 mL 1.6733 mL 4.1833 mL
20 mM 0.1255 mL 0.6275 mL 1.2550 mL 3.1375 mL
25 mM 0.1004 mL 0.5020 mL 1.0040 mL 2.5100 mL
30 mM 0.0837 mL 0.4183 mL 0.8367 mL 2.0916 mL
40 mM 0.0627 mL 0.3137 mL 0.6275 mL 1.5687 mL
50 mM 0.0502 mL 0.2510 mL 0.5020 mL 1.2550 mL
60 mM 0.0418 mL 0.2092 mL 0.4183 mL 1.0458 mL
80 mM 0.0314 mL 0.1569 mL 0.3137 mL 0.7844 mL
100 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6275 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Camostat59721-28-7Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasestrypsinpancreatic fibrosispancreatic stellate cellInhibitorinhibitorinhibit

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目录号：
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