2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Adrenergic Receptor Caspase Bcl-2 Family
  4. Carteolol

Carteolol  (Synonyms: OPC-1085)

目录号: HY-17495
产品使用指南

摩尔计算器

Carteolol 是一种非选择性 β-肾上腺素受体拮抗剂 (β-adrenoceptor)。Carteolol 通过半胱天冬酶激活和线粒体依赖性途径诱导细胞凋亡。Carteolol 可用于青光眼研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Carteolol Chemical Structure

Carteolol Chemical Structure

CAS No. : 51781-06-7

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Carteolol 的其他形式现货产品:

Customer Review

Other Forms of Carteolol:

Carteolol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research[1].

体外研究
(In Vitro)

Carteolol (0-2%; 0-28 hours; HCECs) has cytotoxicity and decreases cell viability in a dose- and time-dependent manner[1].
Carteolol (0.25%; 4-12 hours; HCECs) induces apoptosis and necroptotic protein expression in HCECs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carteolol 相关抗体:

Cell Viability Assay[1]

Cell Line: HCECs
Concentration: 0.00390625-2%
Incubation Time: 0, 2, 4, 8, 16, 20,24 and 28 hours
Result: Decreased cell viability with the concentrations above 0.0015625% in a dose- and time-dependent manner.

Western Blot Analysis[1]

Cell Line: HCECs
Concentration: 0.25%
Incubation Time: 4, 8 and 12 hours
Result: Dampened expression of the anti-apoptotic protein Bcl-2 and Bcl-xL, enhanced expression of the pro-apoptotic proteins Bax and Bad, and mitochondrial-released pro-apoptotic proteins Cyt.c and AIF.

Cell Cycle Analysis[1]

Cell Line: HCECs
Concentration: 0.25%
Incubation Time: 4, 8 and 12 hours
Result: Increased the number of G1 phase of the cell cycle, whereas decreased S phase.
Clinical Trial
分子量

292.37

Formula

C16H24N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carteolol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carteolol51781-06-7OPC-1085OPC1085OPC 1085Adrenergic ReceptorCaspaseBcl-2 FamilyBeta Receptorcytotoxicitynecroptosisapoptosiscorneal endothelial cellsInhibitorinhibitorinhibit

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目录号：
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