Cefamandole nafate  (Synonyms: 头孢孟多酯钠; Cefamandole formate sodium)

Cefamandole nafate (Cefamandole formate sodium) is a second-generation broad-spectrum cephalosporin antibiotic^[1].

Cefamandole nafate is shown to be rapidly converted to cefamandole in bacteriological media, with a half-life of less than 1 h at a pH of 7.0 or above. At pH 6.0, in log-phase inhibition experiments, however, Cefamandole nafate is more stable, allowing delineation of the activity between cefamandole and cefamandole nafate^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

The toxicity of Cefamandole nafate administered iv Is studied in rats receiving doses of 250-1,000 mg/kgfive days per week for one month^[1].
After the administration of Cefamandole nafate for one month, there are no treatment-related adverse effects on growth, food consumption, clinical chemistry, hematology, or organ weights^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

512.49

C₁₉H₁₇N₆NaO₆S₂

42540-40-9

固体

White to off-white

头孢羟唑甲酸钠

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

• [1]. J S Wold, et al. Toxicologic evaluation of cefamandole nafate in laboratory animals. J Infect Dis. 1978 May;137 Suppl:S51-S59.  [Content Brief]

  [2]. J R Turner, et al. Delineation of the relative antibacterial activity of cefamandole and cefamandole nafate. Antimicrob Agents Chemother. 1977 Jul;12(1):67-72.  [Content Brief]