Cefquinome  (Synonyms: 头孢喹咪)

Cefquinome is a broad-spectrum cephem antibiotic that has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, including Staphylococci, Streptococci, Pseudomonas, and Enterobacteriaceae^[1][2][3].

Cefquinome 与青霉素结合蛋白 (PBP) 结合，从而抑制细菌细胞壁的合成^[3]。
Cefquinome 可抑制 methicillin susceptible S. aureus，Streptococcus spp.，Enterococci，E. coli，Salmonella spp.，Klebsiella spp.，S. marcescens，Enterobacter spp.，Citrobacter spp.，P. mirabilis，Indole-positive Proteus spp.，P. aeruginosa，MIC 为 0.006-6.25 μg/mL^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cefquinome（12.5 mg/kg，尾静脉注射，单剂量）在大鼠肺炎模型中表现出对抗肺炎克雷伯菌 Klebsiella pneumoniae 的抗感染活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

528.60

C₂₃H₂₄N₆O₅S₂

84957-30-2

头孢喹咪

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chin NX, et al. In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics. Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):331-7.  [Content Brief]

  [2]. Qu S, et al., Cefquinome-loaded microsphere formulations against Klebsiella pneumonia infection during experimental infections. Drug Deliv. 2018 Nov;25(1):909-915.  [Content Brief]

  [3]. Limbert M, et al., Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1991 Jan;35(1):14-9.  [Content Brief]