2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. Ceralasertib formate

Ceralasertib formate  (Synonyms: AZD-6738 formate)

目录号: HY-123502
产品使用指南 技术支持

Ceralasertib formate 是一种有效、选择性且具有口服活性的 ATR 抑制剂，其 IC50 值为 1 nM。Ceralasertib formate 可抑制细胞活力并诱导 DNA 损伤。Ceralasertib formate 可诱导细胞衰老。Ceralasertib formate 具有抗肿瘤活性。

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Ceralasertib formate Chemical Structure

Ceralasertib formate Chemical Structure

CAS No. : 1352280-98-8

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Ceralasertib formate 的其他形式现货产品:

Other Forms of Ceralasertib formate:

Ceralasertib formate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 46 篇科研文献

WB

    Ceralasertib formate purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2022 Nov 16;41(1):323.  [Abstract]

    Ceralasertib (AZD6738; 1, 2 µM) signifcantly decreases the protein levels of ATR, IFI16 and HuR in a dose-dependent manner in GSC 267 and GSC 20 cells.

    查看 ATM/ATR 亚型特异性产品:

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    ATM ATR

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity[1][2].

    体外研究
    (In Vitro)

    Ceralasertib formate (0, 0.3, 1 μM; 48 h) 以剂量依赖性方式诱导 A549 细胞衰老[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Ceralasertib formate 相关抗体:
    分子量

    458.53

    Formula

    C20H24N6O2S.xCH2O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Ceralasertib formate 相关分类

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    • 稀释计算器

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ceralasertib formate1352280-98-8AZD-6738 formateATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedorally activeDNA damagesenescenceantitumorNSCLCA549 cellsInhibitorinhibitorinhibit

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