2. Apoptosis
  3. Apoptosis
  4. CITCO

CITCO 是一种组成型雄甾烷 (Constitutive androstane) 受体激动剂，抑制脑肿瘤干细胞 (BTSCs) 的生长和扩增。CITCO 是一种咪唑并噻唑衍生物，其作为人 CAR 的选择性激动剂起作用。CITCO 对于孕烷 X 受体 (PXR) 的 EC50 为 49 nM，并且对其他核受体没有活性。

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CITCO Chemical Structure

CITCO Chemical Structure

CAS No. : 338404-52-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥770
In-stock
1 mg ￥335
In-stock
5 mg ￥700
In-stock
10 mg ￥1100
In-stock
25 mg ￥2000
In-stock
50 mg ￥3200
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

CITCO 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CITCO, an imidazothiazole derivative, is a selective Constitutive androstane receptor (CAR) agonist. CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors[1].

IC50 & Target

CAR, PXR[1]
体外研究
(In Vitro)

CITCO (1-50 μM; 48 hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs[1].
CITCO (2.5, 5 μM; 48 hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes[1].
CITCO (2.5-10 μM; 48 hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes[1].
CITCO (0-25 μM; 48 hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein that increased significantly[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CITCO 相关抗体:

Cell Proliferation Assay[1]

Cell Line: T98G, U87MG, DB29 and DB33 human glioma cells, astrocytes
Concentration: 1, 2.5, 5, 10, 25, 50 μM
Incubation Time: 48 hours
Result: Resulted in a dose-dependent inhibition of viable cell count and proliferation.

Cell Cycle Analysis[1]

Cell Line: The T98G, U87MG, DB29 and DB33 glioma cells
Concentration: 2.5, 5 μM
Incubation Time: 48 hours
Result: Induced cell cycle arrest differentially in different BTSCs in culture.

Apoptosis Analysis[1]

Cell Line: The T98G, U87MG, DB29 and DB33 glioma cells
Concentration: 2.5, 5 or 10 μM
Incubation Time: 48 hours
Result: Increased the levels of Annexin V-positive apoptotic cells in dose dependently.

Western Blot Analysis[1]

Cell Line: T98G, U87MG, DB29 and DB33 glioma cells
Concentration: 0 to 25 μM
Incubation Time: 48 hours
Result: The T98G, U87MG glioma and BTSCs expressed very low levels of CAR protein that increased significantly.
体内研究
(In Vivo)

CITCO (intraperitoneal; on days 22, 24, 26, 30 and 36) with 25 μg results a significant decrease in tumour growth, which further decreases to an undetectable level after treatment with 100 μg CITCO [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six- to eight-week-old male athymic nude mice[1]
Dosage: 25 or 100 μg
Administration: Intraperitoneal; on days 22, 24, 26, 30 and 36
Result: Decreased tumour growth.
分子量

436.74

Formula

C19H12Cl3N3OS
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (57.24 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2897 mL 11.4485 mL 22.8969 mL
5 mM 0.4579 mL 2.2897 mL 4.5794 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.60%

COA (202 KB) LCMS (95 KB)

产品使用指南 (1538 KB)
参考文献

CITCO 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2897 mL 11.4485 mL 22.8969 mL 57.2423 mL
5 mM 0.4579 mL 2.2897 mL 4.5794 mL 11.4485 mL
10 mM 0.2290 mL 1.1448 mL 2.2897 mL 5.7242 mL
15 mM 0.1526 mL 0.7632 mL 1.5265 mL 3.8162 mL
20 mM 0.1145 mL 0.5724 mL 1.1448 mL 2.8621 mL
25 mM 0.0916 mL 0.4579 mL 0.9159 mL 2.2897 mL
30 mM 0.0763 mL 0.3816 mL 0.7632 mL 1.9081 mL
40 mM 0.0572 mL 0.2862 mL 0.5724 mL 1.4311 mL
50 mM 0.0458 mL 0.2290 mL 0.4579 mL 1.1448 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CITCO338404-52-7ApoptosisInhibitorinhibitorinhibit

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目录号：
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