2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Anti-infection Apoptosis NF-κB Metabolic Enzyme/Protease
  3. Histamine Receptor Parasite MDM-2/p53 NF-κB FOXO Bacterial
  4. Conessine dihydrobromide

Conessine dihydrobromide 是一种口服有效且能透过血脑屏障的选择性组胺 H3 受体拮抗剂。Conessine dihydrobromide 对大鼠和人 H3 受体的 pKi 为 7.61 和 8.27。Conessine dihydrobromide 是 Pseudomonas aeruginosa 中多药物外排泵系统的抑制剂，可增强抗生素的活性。Conessine dihydrobromide 具有抗疟疾活性。Conessine dihydrobromide 也可用于肌肉萎缩的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Conessine dihydrobromide Chemical Structure

Conessine dihydrobromide Chemical Structure

CAS No. : 5913-82-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Conessine dihydrobromide 的其他形式现货产品:

Other Forms of Conessine dihydrobromide:

Conessine dihydrobromide 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 FOXO 亚型特异性产品:

查看所有亚型
FOXO1 FOXO3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Conessine dihydrobromide is an orally active and BBB-penetrable selective histamine H3 receptor antagonist. The pKi values of Conessine dihydrobromide for rat and human H3 receptors are 7.61 and 8.27, respectively. Conessine dihydrobromide is an inhibitor of the multidrug efflux pump system in Pseudomonas aeruginosa and can enhance the activity of antibiotics. Conessine dihydrobromide has antimalarial activity. Conessine dihydrobromide can also be used in the research of muscle atrophy[1][2][3][4][5].

体外研究
(In Vitro)

Conessine (2.5-20 μM; 24 h) dihydrobromide 在 HEK293 细胞中，可抑制 p53、NF-κB 和 FoxO3a 依赖的转录[1]。
Conessine (10 μM) dihydrobromide 在 Dexamethasone (HY-14648) 处理的 C2C12 肌管细胞中，降低了 MuRF1 和 atrogin-1 水平[1]。
Conessine (72 h) dihydrobromide 具有抗疟原虫活性，在裂殖体成熟法和 pLDH 测定法中的 IC50 分别为 1.9 和 1.3 μg/mL[2]。
Conessine (74 h) dihydrobromide 对 L-6 细胞具有透毒性，IC50 为 14 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Conessine dihydrobromide 相关抗体:
体内研究
(In Vivo)

Conessine (10-50 mg/kg; 口服; 4 天) dihydrobromide 显著降低感染 P. berghei 小鼠的寄生虫血症[2]。
Conessine (0.1-10 mg/kg; 皮下注射; 单剂量) dihydrobromide 能在小鼠中加剧乙醇诱导的精神刺激作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice aged 4-6 weeks old (22-26 g) were infected with Plasmodium berghei[2]
Dosage: 10, 20 and 50 mg/kg
Administration: Oral administration; 4 days
Result: Significantly reduced parasitaemia in infected mice. The parasite inhibition rates were 88.95% at 10 mg/kg, 56.6% at 20 mg/kg, and 50.99% at 50 mg/kg on day 7. The mean survival time of mice in the 10 mg/kg group was 13.3 days, in the 20 mg/kg group was 11.6 days, and in the 50 mg/kg group was 11.5 days.
Affected the liver and kidney function of mice, as shown by the changes in the levels of alkaline phosphatase (ALP), bilirubin, urea, and creatinine in serum.
Animal Model: Male Swiss mice (30-35 g) treated ethanol[3]
Dosage: 0.1, 1 and 10 mg/kg
Administration: Subcutaneously; single dose
Result: Exacerbated ethanol effects on locomotor activity in a dose-dependent manner.
Had reinforcing proprieties per se in the conditionedplace preference (CPP) procedure at dose of 10 mg/kg, but it did not alter the acquisition of ethanol CPP.
Blocked ethanol effects on dopaminergic and noradrenergic neurotransmission.
分子量

518.41

Formula

C24H42Br2N2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Conessine dihydrobromide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conessine dihydrobromide5913-82-6Histamine ReceptorParasiteMDM-2/p53NF-κBFOXOBacterialNuclear factor-κBNuclear factor-kappaBForkhead box Ohistamine H3 receptormalarialinfectionparasitaemia model HEK293 cellsC2C12 myotube cellsL-6 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Conessine dihydrobromide
目录号：
HY-107566A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z