2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Conopeptide rho-TIA

Conopeptide rho-TIA 是一种从掠食性海螺 Conus tulipa 所含毒液中提取的多肽，是人 α1B-Adrenergic Receptor 的非竞争性抑制剂。Conopeptide rho-TIA 是人α1A-Adrenergic Receptor 和 α1D-Adrenergic Receptor 的竞争性抑制剂。Conopeptide rho-TIA 与每种亚型的结合可能为开发新型 α1-Adrenergic Receptor 亚型选择性药物提供有用信息。

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Conopeptide rho-TIA Chemical Structure

Conopeptide rho-TIA Chemical Structure

CAS No. : 381725-58-2

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Conopeptide rho-TIA 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs[1].

IC50 & Target[1]

α1B Adrenergic Receptor

 

α1A Adrenergic Receptor

 

α1D Adrenergic Receptor

 

体外研究
(In Vitro)

Conopeptide rho-TIA (100 nM, 24-48 h) 以非竞争性、可逆的方式与人 α1B-Adrenergic Receptor，这表明conopeptide rho-TIA 可能是一种异位抑制剂[1]。
Conopeptide rho-TIA (30 nM, 2 h) 对人 α1B-Adrenergic Receptor 是一种非竞争性抑制剂，而对α1A-Adrenergic Receptor 和 α1D-Adrenergic Receptor 亚型则是一种竞争性抑制剂[1]。
Conopeptide rho-TIA (10 μM, one time) 抑制去甲肾上腺素引发的 α1 肾上腺素受体介导的胞浆 Ca2+ 浓度升高，但不影响突触前 α2 肾上腺素受体介导的反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Conopeptide rho-TIA 相关抗体:
分子量

2390.88

Formula

C105H160N36O21S4
CAS 号
Sequence

Phe-Asn-Trp-Arg-Cys-Cys-Leu-Ile-Pro-Ala-Cys-Arg-Arg-Asn-His-Lys-Lys-Phe-Cys-NH2 (Disulfide bridge: Cys5-Cys11, Cys6-Cys19)
Sequence Shortening

FNWRCCLIPACRRNHKKFC-NH2 (Disulfide bridge: Cys5-Cys11, Cys6-Cys19)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Conopeptide rho-TIA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conopeptide rho-TIA381725-58-2Adrenergic ReceptorBeta Receptorselectivenoncompetitiveα1 Adrenergic ReceptorConus tulipaHEK293Inhibitorinhibitorinhibit

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