2. Immunology/Inflammation
  3. Interleukin Related
  4. CTX-471

CTX-471 

目录号: HY-P99178 纯度: 99.42%
COA

摩尔计算器

CTX-471 是 CD137 的全人源单克隆抗体。CTX-471 对重组人、食蟹猴 CD137 和小鼠 CD137 具有结合亲和力，Kd 值分别为 50 nM、61 nM 和 748 nM。CTX-471 可用于免疫调节和癌症的研究。

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CTX-471 Chemical Structure

CTX-471 Chemical Structure

CAS No. : 2377152-49-1

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规格 价格 是否有货 数量
1 mg ￥5400
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Customer Review

CTX-471 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer[1].

IC50 & Target

Kd for CD137: 50 nM (human); 61 nM (cynomolgus macaque); 748 nM (mouse)[1]
体外研究
(In Vitro)

CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively[1].
CTX-471 binds to a unique epitope on CD137[1].
CTX-471 (0.1-100 nM; 1, 10 μg/mL; 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CTX-471 相关抗体:
体内研究
(In Vivo)

CTX-471 (i.p.; 150 μg) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors. CTX-471 (i.v.; 10-80 mg/kg; on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[1]
Dosage: 150 μg;
10-80 mg/kg
Administration: i.p., on days 6, 9, 12, 19 and 26( or on days 7, 10, 13, 20, and 27 or on days 0, 3, 6, and 9);
i.v., on days 0, 7, 14, and 21
Result: Required T and NK cells, as well as FcγR engagement to achieve its efficacy.
Do not induce hepatic inflammation.
Clinical Trial
Formula

CT
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CTX-471 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CTX-4712377152-49-1CTX471CTX 471Interleukin RelatedILTNF receptor superfamily (TNFRSF)Cell surface glycoprotein CD137immune receptorstumormonoclonal antibodyimmunomodulationInhibitorinhibitorinhibit

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