1. Anti-infection Immunology/Inflammation Metabolic Enzyme/Protease
  2. Fungal PD-1/PD-L1 Cytochrome P450
  3. CYP51/PD-L1-IN-1

CYP51/PD-L1-IN-1 (compound L11) 是一种喹唑啉化合物,具有抗真菌活性。CYP51/PD-L1-IN-1 是 CYP51 (IC50: 0.884 μM) 和 PD-L1 (IC50: 0.083 μM) 的双重抑制剂,可诱导真菌细胞在细胞周期发生早期凋亡 (apoptosis)。CYP51/PD-L1-IN-1 还显著降低细胞内 IL-2、NLRP3、NF-κBp65 蛋白水平,诱导线粒体损伤和 ROS 聚集,最终导致真菌裂解和死亡。

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CYP51/PD-L1-IN-1 Chemical Structure

CYP51/PD-L1-IN-1 Chemical Structure

CAS No. : 3032386-49-2

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  • 生物活性

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生物活性

CYP51/PD-L1-IN-1 (compound L11) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-1 is a dual inhibitor of CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-1 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death[1].

IC50 & Target

IC50: 0.884 μM (CYP51), 0.083 μM (PD-L1)[1]

分子量

357.37

Formula

C20H15N5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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产品名称:
CYP51/PD-L1-IN-1
目录号:
HY-156149
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