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    PROTAC
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    PROTAC
  3. dBET57

dBET57 

目录号: HY-123844
产品使用指南

dBET57 是一种有效选择性的 BRD4 异源双功能降解剂,基于 PROTAC 技术,对 BRD4BD1 作用的 DC50/5h 值为 500 nM,对 BRD4BD2 不起作用。

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dBET57 Chemical Structure

dBET57 Chemical Structure

CAS No. : 1883863-52-2

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Description

dBET57 is a potent and selective heterobifunctional degrader of BRD4 based on the PROTAC technology, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2[1].

IC50 & Target

DC50/5h: 500 nM (BRD4BD1)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

699.18

Formula

C₃₄H₃₁ClN₈O₅S

CAS No.

1883863-52-2

SMILES

O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
dBET57
目录号:
HY-123844
需求量:

dBET57

Cat. No.: HY-123844