2. Epigenetics
  3. WDR5
  4. DDO-2213

DDO-2213 是一种口服有效的 WDR5-MLL1 抑制剂，对 WDR5 蛋白的 IC50 为 29 nM，Kd 值为 72.9 nM。 DDO-2213 选择性抑制 MLL（混合谱系白血病）组蛋白甲基转移酶活性和 MLL 易位细胞的增殖。 DDO-2213 可用于 MLL 融合白血病研究。

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DDO-2213 Chemical Structure

DDO-2213 Chemical Structure

CAS No. : 2378768-36-4

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DDO-2213 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HUVEC IC50
> 100 μM
Compound: 63; DDO-2213
Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
K562 IC50
> 100 μM
Compound: 63; DDO-2213
Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
MOLM-13 GI50
13.09 μM
Compound: DDO-2213
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
[PMID: 34283608]
MOLM-13 IC50
13.1 μM
Compound: 63; DDO-2213
Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
MV4-11 GI50
12.57 μM
Compound: DDO-2213
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
[PMID: 34283608]
MV4-11 IC50
12.6 μM
Compound: 63; DDO-2213
Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
分子量

483.97

Formula

C24H27ClFN7O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (258.28 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0662 mL 10.3312 mL 20.6624 mL
5 mM 0.4132 mL 2.0662 mL 4.1325 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DDO-2213 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0662 mL 10.3312 mL 20.6624 mL 51.6561 mL
5 mM 0.4132 mL 2.0662 mL 4.1325 mL 10.3312 mL
10 mM 0.2066 mL 1.0331 mL 2.0662 mL 5.1656 mL
15 mM 0.1377 mL 0.6887 mL 1.3775 mL 3.4437 mL
20 mM 0.1033 mL 0.5166 mL 1.0331 mL 2.5828 mL
25 mM 0.0826 mL 0.4132 mL 0.8265 mL 2.0662 mL
30 mM 0.0689 mL 0.3444 mL 0.6887 mL 1.7219 mL
40 mM 0.0517 mL 0.2583 mL 0.5166 mL 1.2914 mL
50 mM 0.0413 mL 0.2066 mL 0.4132 mL 1.0331 mL
60 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8609 mL
80 mM 0.0258 mL 0.1291 mL 0.2583 mL 0.6457 mL
100 mM 0.0207 mL 0.1033 mL 0.2066 mL 0.5166 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-22132378768-36-4DDO2213DDO 2213WDR5WD repeat protein-5WD40 repeat domain protein 5MLL Fusion LeukemiaWD repeat-containing protein 5MV4-11 tumorInhibitorinhibitorinhibit

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目录号：
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