2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Desipramine

Desipramine 是一种三环类的精神类化合物，具有抗抑郁活性。Desipramine 可抑制中枢神经系统的去甲肾上腺素再摄取受体 (norepinephrine reuptake receptor)，减少睡眠引起的腮舌肌活性丧失，可用于研究改善咽塌陷。

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Desipramine Chemical Structure

Desipramine Chemical Structure

CAS No. : 50-47-5

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Desipramine 的其他形式现货产品:

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Other Forms of Desipramine:

Desipramine 相关抗体

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查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Desipramine is a tricyclic psychotic compound, possessing antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activity, can be used to research the improvement of pharyngeal collapsibility[1][2].

IC50 & Target

Norepinephrine Reuptake Receptor[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DG-75 IC50
39.81 μM
Compound: Desipramine
Reduction in cell viability of human DG75 cells after 24 hrs by Alamar blue viability assay
Reduction in cell viability of human DG75 cells after 24 hrs by Alamar blue viability assay
[PMID: 23385211]
HEK293 IC50
1520 nM
Compound: Desipramine
Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA
Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA
[PMID: 21300721]
HEK293 IC50
56.8 μM
Compound: desipramine
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
[PMID: 18788725]
HEK293 IC50
9.18 μM
Compound: Desipramine
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay
[PMID: 28230985]
HeLa IC50
17.78 μM
Compound: Desipramine
Reduction in cell viability of human HeLa cells after 24 hrs by Alamar blue viability assay
Reduction in cell viability of human HeLa cells after 24 hrs by Alamar blue viability assay
[PMID: 23385211]
MDCK IC50
0.93 nM
Compound: desipramine
Displacement of [125I]RTI55 from human recombinant norepinephrine transporter expressed in MDCK cells after 3 hrs
Displacement of [125I]RTI55 from human recombinant norepinephrine transporter expressed in MDCK cells after 3 hrs
[PMID: 23403082]
Splenocyte IC50
22.9 μM
Compound: Desipramine
Cytotoxicity against C57BL/6J mouse splenocytes after 72 hrs by alamar blue assay
Cytotoxicity against C57BL/6J mouse splenocytes after 72 hrs by alamar blue assay
[PMID: 17846138]
Ventricular myocyte IC50
1.709 μM
Compound: Desipramine
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
[PMID: 22761000]
Ventricular myocyte IC50
11.7 μM
Compound: Desipramine
Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes
[PMID: 22761000]
Ventricular myocyte IC50
1709 nM
Compound: Desipramine
Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes
Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes
[PMID: 21300721]
Clinical Trial
分子量

266.38

Formula

C18H22N2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Desipramine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desipramine50-47-5Adrenergic ReceptorBeta ReceptorantidepressantnorepinephrinegenioglossuspharyngealInhibitorinhibitorinhibit

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目录号：
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