1. PROTAC Apoptosis
  2. PROTACs Bcl-2 Family Apoptosis
  3. dMCL1-2

dMCL1-2 是一种基于 Cereblon 配体的,高效、选择性的 MCL1 (Bcl-2家族成员) 降解剂,结合 MCL1 的 KD 值为 30 nM。dMCL1-2 通过降解 MCL1 激活细胞凋亡。

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dMCL1-2 Chemical Structure

dMCL1-2 Chemical Structure

CAS No. : 2351218-88-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

dMCL1-2 is a potent and selective PROTAC of myeloid cell leukemia 1 (MCL1) (Bcl-2 family member) based on Cereblon, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1].

IC50 & Target

KD: 30 nM (MCL1)[1]

分子量

1163.30

Formula

C61H66N10O12S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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dMCL1-2
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HY-128360
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