1. Anti-infection Metabolic Enzyme/Protease
  2. Parasite Dihydroorotate Dehydrogenase
  3. DSM1465

DSM1465 (Compound 82) 是一种有效的选择性 P. falciparum 二氢酸脱氢酶 (PfDHODH) 抑制剂,IC50 值为 15 nM,抑制 P. falciparum 3D7 (Pf3D7) 寄生虫,EC50 值为 1.4 nM。DSM1465 在人源化的 P. falciparum 小鼠模型中显示出强大的体内活性。

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DSM1465 Chemical Structure

DSM1465 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].

分子量

467.75

Formula

C17H12ClF6N5O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
DSM1465
目录号:
HY-170780
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