2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. DSP30

DSP30 是一种硫代磷酸酯 CpG 序列的寡脱氧核苷酸和 TLR9 激动剂。DSP30 能够激活免疫系统细胞，包括 B 细胞和树突状细胞，通过诱导增殖和细胞因子产生发挥作用。DSP30 能增强骨髓来源间充质基质细胞 (BM-MSC) 的免疫抑制功能。DSP30 与白介素2 (IL2) 联合使用是 B 细胞疾病的有效有丝分裂刺激剂。DSP30 可用于慢性淋巴细胞白血病的遗传特性研究分析。

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TCGTCGCTGTCTCCGCTTCTTCTTGCC

DSP30 Chemical Structure

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DSP30 相关抗体

Top Publications Citing Use of Products

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DSP30 is a phosphorothioate cpG-oligodeoxynucleotide and a TLR9 agonist. DSP30 can activate immune system cells, including B cells and dendritic cells, by inducing proliferation and cytokine production.DSP30 can enhance the immunosuppressive function of bone marrow-multipotent mesenchymal stromal cells (BM-MSC). DSP30 combined with interleukin 2 (IL2) is an effective mitotic stimulant in B-cell disorders. DSP30 can be used for the genetic characteristic research and analysis of chronic lymphocytic leukemia (CLL)[1][2][3][4][5].

体外研究
(In Vitro)

DSP30 (1 μM, 5 天) 通过促进 BM-MSC 增殖，上调 TGF-β1 等抗炎因子，维持共培养 T 细胞 IFN-γ 和 IL-10 的高表达和增强腺苷水平增强了 BM-MSC 的免疫抑制功能[1]。
DSP30 (10 μg/mL, 5 天) 能够使 CRTH2+ 变应原刺激的 TH2 细胞产生 IFN-γ[4]。
DSP30 (0.1-1 μM, 0-72 h) 显著上调了 B-CLL 细胞中 CD25 的表达[5]。
DSP30 (0.01-1 μM, 48-120 h) 显著增强 LMB-2 对 B-CLL 细胞的杀伤作用[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DSP30 相关抗体:

RT-PCR[1]

Cell Line: BM-MSC, T lymphocytes
Concentration: 1 μM
Incubation Time: 5 days
Result: Had no impact on the expression of the inflammatory cytokine IL-6.
Induced the expression of IL-1β, IL-8 and TGF-β1.
Led to a significant increase in IL-8 and VCAM expression levels with LSP stimulation.
Maintained the high expression of IFN-γ and IL-10 in T cells with upregulated BM-MSC.

Cell Viability Assay[5]

Cell Line: B-CLL cells
Concentration: 1 μM
Incubation Time: 5 days
Result: Significantly enhance the sensitivity of B-CLL cells to LMB-2.
Enable the originally drug-resistant B-CLL cells to reach the clinically achievable IC50 level.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DSP30 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSP30DSP 30DSP-30Toll-like Receptor (TLR)OligonucleotideBM-MSCIL2B-cell disorderImmunosuppressionInhibitorinhibitorinhibit

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HY-177058
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