1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Durvalumab

Durvalumab  (Synonyms: 德瓦鲁单抗; MEDI 4736)

目录号: HY-P9919 纯度: 99.60%
COA

Durvalumab (MEDI 4736) 是一种人源的抗 PD-L1 蛋白单克隆抗体。Durvalumab (MEDI 4736) 完全阻断 PD-L1PD-1CD80 结合, IC50 分别为 0.1 和 0.04 nM。

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Durvalumab Chemical Structure

Durvalumab Chemical Structure

CAS No. : 1428935-60-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Durvalumab (MEDI 4736) is an human anti-PD-L1 monoclonal antibody[1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively[2].

IC50 & Target

IC50: 0.1 nM (PD-L1/PD-1), 0.04 nM (PD-L1/CD80)[2]

体内研究
(In Vivo)

Durvalumab inhibits tumor growth in mouse xenograft models of human melanoma (A375) and pancreatic (HPAC) tumour cell lines, via a T-cell-mediated mechanism. Durvalumab (5-0.01 mg/kg for NOD/SCID mice with HPAC tumor; 5-0.1 mg/kg for NOD/SCID mice with A375 tumor; administration i.p.; twice per week; for 3 weeks) significantly inhibits the tumor growth of both HPAC and A375 xenografts compared with an isotype-matched control antibody. Tumor growth inhibition of the HPAC cells reaches 74%, whereas inhibition of the A375 cells reaches 77%. When administered in the absence of T cells, Durvalumab has no effect on the growth of the A375 tumor xenograft[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice with HPAC tumor, following coimplantation of primary human T cells; NOD/SCID mice with A375 tumor, following coimplantation of primary human T cells[2]
Dosage: 5, 1, 0.1, and 0.01 mg/kg for NOD/SCID mice with HPAC tumor; 5, 1, and 0.1 mg/kg for NOD/SCID mice with A375 tumor
Administration: Administration i.p.; twice per week; for 3 weeks
Result: Significantly inhibited the tumor growth of both HPAC and A375 xenografts compared with an isotype-matched control antibody.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

度伐单抗;德瓦鲁单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 99.60%

参考文献

Durvalumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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