2. MAPK/ERK Pathway Cell Cycle/DNA Damage Apoptosis
  3. MNK Eukaryotic Initiation Factor (eIF) Apoptosis
  4. EB1

EB1 是 MNK 激酶的抑制剂，IC50 分别为 0.69 μM (MNK1) 和 9.4 μM (MNK2)。EB1 选择性地抑制癌细胞的生长，不抑制正常细胞的生长。EB1 还增加细胞凋亡，抑制 eIF4E 磷酸化。

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EB1 Chemical Structure

EB1 Chemical Structure

CAS No. : 42951-68-8

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EB1 相关抗体

Top Publications Citing Use of Products

查看 MNK 亚型特异性产品:

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MNK1 MNK2 MNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2].

IC50 & Target[1]

MNK1

0.69 μM (IC50)

MNK2

9.4 μM (IC50)

eIF4E

 

体外研究
(In Vitro)

EB1（1.3-40 μM；24 小时）剂量依赖性地抑制 eIF4E 的磷酸化[1]。
EB1（2.5-40 μM；72 小时）对肿瘤细胞显示出剂量依赖性细胞毒性，并诱导细胞凋亡[1]。
EB1（5 μM、10 μM 和 20 μM；24 小时）直接作用于 MNK 激酶，而不会干扰激活上游信号，例如 p38 的激活 (p-p38) 及其下游效应子 HSP27 的磷酸化[1]。
EB1 (compound 14) 抑制癌细胞 HepG2 和 MCF-7 的 IC50 分别为 0.74 μM 和 5.18 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EB1 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells
Concentration: 1.3 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 24 hours
Result: Blocked the phosphorylation of eIF4E in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231, MDA-MB-468, MCF7, and IMR90 cells
Concentration: 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 72 hours
Result: Increased the percentage of apoptosis cells among tumor cells.
分子量

286.33

Formula

C18H14N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EB1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EB142951-68-8EB 1EB-1MNKEukaryotic Initiation Factor (eIF)ApoptosisMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseInhibitorinhibitorinhibit

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