Efbemalenograstim alfa  (Synonyms: Benegrastim; Bineuta; F 627)

Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells^[1].

Efbemalenograstim alfa 可激活 STAT3 信号通路，促进 32D-GCSFR 和 M-NSF60 细胞增殖^[2]。
Efbemalenograstim alfa 可增加绝对中性粒细胞计数 (ANC)，加速中性粒细胞恢复，因此可用于中性粒细胞减少症的研究^[2][3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Efbemalenograstim alfa（10-150 µg/kg，皮下注射，每 5 天一次，共 2 次）可在接受 Cyclophosphamide (HY-17420) 的食蟹猴体内减少绝对中性粒细胞计数，改善化疗引起的中性粒细胞减少症^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

89.24 kDa

2200269-79-8

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  [CSF3 (colony stimulating factor 3, GCSF, granulocyte colony-stimulating factor, G-CSF)]2-IGHG2

• 
  Immobilized Efbemalenograstim alfa can bind Human CSF3R/G-CSFR Protein (His Tag). The EC₅₀ for this effect is 7.65 ng/mL.

• [1]. Daley W, et, al. Evive successfully concludes first phase III clinical trial of F-627 for chemotherapy-induced neutropenia and met primary endpoints. Shanghai, China: Evive Biotech; January 25, 2018.

  [2]. Hu Z T, et al. F-627, a G-CSF Dimer, Stimulated a More Rapid Neutrophil Recovery In Cyclophosphamide-Treated Monkeys Compared to Monomer Rhg-CSFs[J]. Blood, 2010, 116(21): 1485.

  [3]. Blair HA. Efbemalenograstim Alfa: First Approval. Drugs. 2023 Aug;83(12):1125-1130.  [Content Brief]