2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-160

EGFR-IN-160 (Compound R12) 是一种 EGFR 抑制剂 (EGFRWT，EGFRT790M 和 EGFRL858R/T790M/C797S 的 IC50 值分别为 1.62，0.49 和 0.98 μM)。EGFR-IN-160 可诱导 NCI-H522 细胞在 G2/M 和 S 期停滞和细胞凋亡 (Apoptosis)，具有抗癌活性。EGFR-IN-160 对 DPPH (IC50: 12.11 µM) 和 H2O2 (IC50: 8.89 µM) 具有抗氧化作用。

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EGFR-IN-160 Chemical Structure

EGFR-IN-160 Chemical Structure

CAS No. : 2172879-84-2

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EGFR-IN-160 相关抗体

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生物活性

EGFR-IN-160 (Compound R12) is an EGFR inhibitor (IC50 values are 1.62, 0.49 and 0.98 μM for EGFRWT, EGFRT790M and EGFRL858R/T790M/C797S, respectively). EGFR-IN-160 induces G2/M and S phase arrest and apoptosis in NCI-H522 cells, and has anticancer activity. EGFR-IN-160 has antioxidant effects against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM)[1].

分子量

284.27

Formula

C15H12N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
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纯度 & 产品资料
参考文献

EGFR-IN-160 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

EGFR-IN-1602172879-84-2EGFREpidermal growth factor receptorErbB-1HER1NCI-H522 cellsanticancerlung cancerNCI-H1975DPPHH2O2Inhibitorinhibitorinhibit

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