2. GPCR/G Protein Apoptosis
  3. Protease Activated Receptor (PAR) Apoptosis
  4. ENMD-1068

ENMD-1068 是一种选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。ENMD-1068 可通过抑制 TGF-β1/Smad 信号转导而减少肝星状细胞的活化和胶原蛋白的表达。ENMD-1068 还能抑制子宫内膜细胞的增殖，并诱导病灶中上皮细胞的凋亡 (apoptosis)。ENMD-1068 可用于子宫内膜异位症、肝纤维化的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ENMD-1068 Chemical Structure

ENMD-1068 Chemical Structure

CAS No. : 789488-77-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

ENMD-1068 的其他形式现货产品:

Customer Review

Other Forms of ENMD-1068:

ENMD-1068 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].

体外研究
(In Vitro)

ENMD-1068（10 mM；24 小时）阻断原代小鼠 HSC 中的 TGF-β1/Smad 信号传导（TGF-β1/Smad 信号通路在 HSC 激活和胶原蛋白生成中发挥着至关重要的作用）[1]。
ENMD-1068 (10 mM) 抑制 HSC 中胰蛋白酶或 SLIGRL-NH2 刺激的钙释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ENMD-1068 相关抗体:

Western Blot Analysis[1]

Cell Line: Hepatic stellate cells (HSCs) (TGF-β1-stimulated)
Concentration: 10 mM
Incubation Time: 24 h
Result: Inhibited TGF-β1-induced expression of α-SMA, Col α1(І),Col α1(III), and Smad2/3 C-terminal phosphorylation.
体内研究
(In Vivo)

ENMD-1068（25、50 mg/kg；腹腔注射；每周两次，持续 4 周）抑制小鼠肝纤维化[1]。
ENMD-1068（25、50 mg/kg；腹腔注射；每日一次，持续 5 天）可抑制子宫内膜异位症生长并以剂量依赖性方式抑制 IL-6 和 MCP-1 水平[2]。
ENMD-1068（25、50 mg/kg；腹腔注射；每天一次，持续 5 天）会导致小鼠上皮细胞增殖减少，细胞凋亡指数增加[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (8-week-old; CCl4-induced liver fibrosis model)[1].
Dosage: 25, 50 mg/kg
Administration: Intraperitoneal injection; twice per week for 4 weeks
Result: Markedly attenuated collagen deposition.
Animal Model: Mice with surgically induced endometriosis[2].
Dosage: 25, 50 mg/kg
Administration: Intraperitoneal injection; single daily for 5 days
Result: Reduced the volume of observed lesions in a dose-dependent manner.
Inhibited the expression of IL-6 and MCP-1.
Decreased the proliferation rate of endometriotic cells and increased the percentage of apoptotic epithelial cells in the lesions.
分子量

283.41

Formula

C15H29N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ENMD-1068 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ENMD-1068789488-77-3ENMD1068ENMD 1068Protease Activated Receptor (PAR)ApoptosisThrombin receptorsendometriosisliver fibrosisHSCsIL-6NF-κBanti-proliferationMCP-1Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ENMD-1068
目录号：
HY-124748
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z