2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Anti-infection
  3. Estrogen Receptor/ERR Endogenous Metabolite Bacterial
  4. Estradiol hemihydrate

Estradiol hemihydrate  (Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate)

目录号: HY-B0141C
产品使用指南 技术支持

Estradiol (β-Estradiol) hemihydrate 是一种类固醇激素和主要的女性性激素。Estradiol (β-Estradiol) hemihydrate 可上调人子宫内膜干细胞 (hEnSCs) 神经标志物的表达并促进其神经分化。Estradiol (β-Estradiol) hemihydrate 可用于癌症、神经退行性疾病和神经组织工程的相关研究。

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Estradiol hemihydrate Chemical Structure

Estradiol hemihydrate Chemical Structure

CAS No. : 35380-71-3

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Estradiol hemihydrate 的其他形式现货产品:

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Estradiol hemihydrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 94 篇科研文献

WB
Cell Viability Assay
RT-PCR

    Estradiol hemihydrate purchased from MCE. Usage Cited in: J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13693.  [Abstract]

    Estradiol (E2) (10-100 nM) exhibites an increase in the SIRT1 protein level in C2C12 cells, without significantly affecting the mRNA level.

    Estradiol hemihydrate purchased from MCE. Usage Cited in: Sci Total Environ. 2024 Jul 6:947:174543.  [Abstract]

    Estradiol (E2) (1 μM, 8 h) alone or in combination with TEB (100 μM, 8 h) (TEB + E2) significantly increases the protein expression levels of FoxL2 and pFoxL2 (Ser238) in ZF4 cells.

    Estradiol hemihydrate purchased from MCE. Usage Cited in: Aging Cell. 2024 Aug 7:e14303.  [Abstract]

    Estradiol (3-25 ng/mouse; s.c.; for 7 consecutive days) significantly ​​decreases​​ LAMIN A levels while ​​increasing​​ PROGERIN and PRELAMIN A levels in the uteri of mice injected with 10 ng or 25 ng, compared to those receiving the 3 ng dose.

    Estradiol hemihydrate purchased from MCE. Usage Cited in: Int J Biol Macromol. 2023 Mar 10;236:123987.  [Abstract]

    Estradiol (1-100 nM; 6-72 h) promotes the proliferation of sheep myoblasts.

    Estradiol hemihydrate purchased from MCE. Usage Cited in: Theranostics. 2020 Aug 29;10(24):10874-10891.  [Abstract]

    Estradiol (E2) (100 nM; 36 h) treatment can enhance the expression of ERRα and VLDL-related genes such as Apob, Mttp and Pla2g12b, whereas the induction is blocked with loss of ERRα in primary hepatocytes.

    Estradiol hemihydrate purchased from MCE. Usage Cited in: Environ Pollut. 2021 Feb 1;270:116015.  [Abstract]

    Estradiol (1-10 nM; 24 h) significantly induces mRNA expression of both pS2 and NRF1 genes in MCF-7 cells.

    查看 Estrogen Receptor/ERR 亚型特异性产品:

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    Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].

    体外研究
    (In Vitro)

    Estradiol hemihydrate (10 nM, 7 days) induces neural differentiation and increased neurite branching of human endometrial stem cells (hEnSCs)[1].
    Estradiol hemihydrate (17β-estradiol, 10 nM, 7 days) increases the expression of neuron-like cell markers (Tuj-1, nestin and NF-H) in neural-like cells differentiated from hEnSCs[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Estradiol hemihydrate 相关抗体:

    Cell Differentiation Assay[1]

    Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
    Concentration: 10 nM
    Incubation Time: 7 days
    Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.

    Immunofluorescence[1]

    Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
    Concentration: 10 nM
    Incubation Time: 7 days
    Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.
    体内研究
    (In Vivo)

    Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1].
    Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: FBN-ARO-KO Mice[2]
    Dosage: 1 nM
    Administration: Treated for the hippocampal slices
    Result: Rescued long-term potentiation (LTP) amplitude of both male and female mice.
    Animal Model: FBN-ARO-KO Mice[2]
    Dosage: 0.0167 mg
    Administration: Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.
    Result: Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain.
    Rescued the spatial learning and memory defects.
    Clinical Trial
    分子量

    281.39

    Formula

    C18H26O3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Estradiol hemihydrate 相关分类

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    Keywords:

    Estradiol hemihydrate35380-71-3β-Estradiol hemihydrate17β-Estradiol hemihydrate17β-Oestradiol hemihydrateEstrogen Receptor/ERREndogenous MetaboliteBacterialEstrogenneural differentiationhuman endometrial stem cellsFBN-ARO-KO modelsteroid sex hormoneuterine fibroidsInhibitorinhibitorinhibit

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