2. Metabolic Enzyme/Protease Autophagy
  3. Dipeptidyl Peptidase Autophagy
  4. Evogliptin

Evogliptin  (Synonyms: DA-1229)

目录号: HY-117985
产品使用指南

摩尔计算器

Evogliptin (DA-1229) 是一种口服有效的 DPP4 抑制剂，在小鼠模型中具有显著而持久的降糖效果。Evogliptin 还可通过诱导自噬来抑制肝细胞的炎症和纤维化信号的产生。Evogliptin 可用于 2 型糖尿病、骨质疏松症，肾功能损害以及慢性肝脏炎症的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Evogliptin tartrate 通常具有更好的水溶性和稳定性。

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Evogliptin Chemical Structure

Evogliptin Chemical Structure

CAS No. : 1222102-29-5

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Evogliptin 的其他形式现货产品:

Customer Review

Other Forms of Evogliptin:

Evogliptin 相关抗体

Top Publications Citing Use of Products

查看 Dipeptidyl Peptidase 亚型特异性产品:

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation[1][2][3][4].

IC50 & Target
体外研究
(In Vitro)

Evogliptin (2.49 mM; 12 h) efficiently inhibits mDPP4 (membrane DPP4) enzymatic activity in PWM-induced H9 Th1 cells[1].
Evogliptin prevents inflammatory and fibrotic signaling through autophagy induction in primary hepatocytes of ATG7f/f-Cre+ mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Evogliptin 相关抗体:

Cell Viability Assay[1]

Cell Line: H9 Th1 cells (pokeweed mitogen (PWM)-induced)
Concentration: 2.49 mM (1 µg/mL)
Incubation Time: 12 h
Result: Potently inhibited mDPP4 (membrane DPP4) activity in a dose-dependent manner but did not affect either the cytokine profile or cell viability in PWM-activated CD4+CD26+ H9 Th1 cells.
体内研究
(In Vivo)

Evogliptin (100, 300 mg/kg; in animal feedings; single daily for 10 weeks) exhibits antidiabetic effects on HFD/STZ mice and improves glucose intolerance and insulin resistance[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (four-week-old; HFD/STZ mice model)[3].
Dosage: 100, 300 mg/kg
Administration: In animal feedings; single daily for 10 weeks
Result: Decreased the blood glucose level from the second weekand persisted through the 10-week treatment, when at 300 mg/kg.
Significantly reduced HbA1c level when dosage at 300 mg/kg.
Significantly decreased 6 h-fasted blood glucose levels in a dose-dependent manner.
Clinical Trial
分子量

401.42

Formula

C19H26F3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Evogliptin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evogliptin1222102-29-5DA-1229DA1229DA 1229Dipeptidyl PeptidaseAutophagyDPPtype 2 diabetesosteoporosisrenal impairmentchronic liver inflammationH9 Th1hepatocytesInhibitorinhibitorinhibit

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