2. Apoptosis
  3. Apoptosis
  4. (E)-Flavokawain A

(E)-Flavokawain A  (Synonyms: (E)-卡瓦胡椒素A)

目录号: HY-N5106 纯度: 99.79%
COA 产品使用指南 技术支持

(E)-Flavokawain A 是从卡瓦胡椒中提取的查尔酮，具有抗癌作用。(E)-Flavokawain A 通过介入 bax 蛋白依赖和线粒体依赖的凋亡通路，诱导膀胱癌细胞凋亡，抑制小鼠肿瘤生长。

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(E)-Flavokawain A Chemical Structure

(E)-Flavokawain A Chemical Structure

CAS No. : 37951-13-6

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规格 价格 是否有货 数量
1 mg ￥191
In-stock
5 mg ￥400
In-stock
10 mg ￥660
In-stock
25 mg ￥1363
In-stock
50 mg ￥2038
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of (E)-Flavokawain A:

(E)-Flavokawain A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 20 μM
Compound: 6
Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
[PMID: 19883086]
A549 IC50
11.6 μg/mL
Compound: Flavokawain A
Inhibition of TNF-alpha-induced NF-kappaB expressed in human A549 cells treated 1 hr after TNFalpha challenge measured after 6 hrs by luciferase reporter gene assay
Inhibition of TNF-alpha-induced NF-kappaB expressed in human A549 cells treated 1 hr after TNFalpha challenge measured after 6 hrs by luciferase reporter gene assay
[PMID: 19716299]
DU-145 GI50
30.8 μM
Compound: 4
Cytotoxicity against human DU145 cells after 48 hrs
Cytotoxicity against human DU145 cells after 48 hrs
[PMID: 18798609]
HCT-116 IC50
10.6 μM
Compound: 1c
Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay
Antiproliferative activity against human HCT116 cells after 48 hrs by SRB assay
[PMID: 30041135]
HT-29 GI50
45.3 μM
Compound: 4
Cytotoxicity against human HT29 cells after 48 hrs
Cytotoxicity against human HT29 cells after 48 hrs
[PMID: 18798609]
K562 GI50
20.5 μM
Compound: 4
Cytotoxicity against human K562 cells after 48 hrs
Cytotoxicity against human K562 cells after 48 hrs
[PMID: 18798609]
M14 GI50
22.5 μM
Compound: 4
Cytotoxicity against human M14 cells after 48 hrs
Cytotoxicity against human M14 cells after 48 hrs
[PMID: 18798609]
MCF7 GI50
17.5 μM
Compound: 4
Cytotoxicity against human MCF7 cells after 48 hrs
Cytotoxicity against human MCF7 cells after 48 hrs
[PMID: 18798609]
MDCK-II IC50
3 μM
Compound: 24
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
[PMID: 22112540]
NCI-H460 GI50
24.1 μM
Compound: 4
Cytotoxicity against human H460 cells after 48 hrs
Cytotoxicity against human H460 cells after 48 hrs
[PMID: 18798609]
NIH3T3 IC50
11 μM
Compound: 2a
Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay
Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay
[PMID: 21112783]
NIH3T3 GI50
17.2 μM
Compound: 4
Cytotoxicity against BALB mouse 3T3 cells after 48 hrs
Cytotoxicity against BALB mouse 3T3 cells after 48 hrs
[PMID: 18798609]
PC-3 GI50
15.2 μM
Compound: 4
Cytotoxicity against human PC3 cells after 48 hrs
Cytotoxicity against human PC3 cells after 48 hrs
[PMID: 18798609]
Vero IC50
> 25 μM
Compound: 4
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 in african green monkey Vero cells after 120 hrs
[PMID: 18798609]
分子量

314.33

Formula

C18H18O5
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

(E)-卡瓦胡椒素A
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (79.53 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1814 mL 15.9069 mL 31.8137 mL
5 mM 0.6363 mL 3.1814 mL 6.3627 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.79%

COA (284 KB) HNMR (250 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

(E)-Flavokawain A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1814 mL 15.9069 mL 31.8137 mL 79.5343 mL
5 mM 0.6363 mL 3.1814 mL 6.3627 mL 15.9069 mL
10 mM 0.3181 mL 1.5907 mL 3.1814 mL 7.9534 mL
15 mM 0.2121 mL 1.0605 mL 2.1209 mL 5.3023 mL
20 mM 0.1591 mL 0.7953 mL 1.5907 mL 3.9767 mL
25 mM 0.1273 mL 0.6363 mL 1.2725 mL 3.1814 mL
30 mM 0.1060 mL 0.5302 mL 1.0605 mL 2.6511 mL
40 mM 0.0795 mL 0.3977 mL 0.7953 mL 1.9884 mL
50 mM 0.0636 mL 0.3181 mL 0.6363 mL 1.5907 mL
60 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3256 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Flavokawain A37951-13-6(E)-卡瓦胡椒素AApoptosisInhibitorinhibitorinhibit

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