2. Gene
  3. DPP3 - dipeptidyl peptidase 3 Gene

DPP3 - dipeptidyl peptidase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二肽基肽酶 3

种属: Homo sapiens

同用名: DPPIII

基因 ID: 10072 | 基因类型: protein coding

关于 DPP3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,480,434-66,509,657 (from NCBI)

This gene has 16 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in colon (RPKM 13.2), appendix (RPKM 10.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是 M49 金属肽酶家族的成员。这种细胞质蛋白通过其锌结合基序 (HELLGH) 结合单个锌离子，并具有脯氨酸后二肽氨肽酶活性，可从蛋白质的 N 末端切割 Xaa-Pro 二肽。这种蛋白质活性的增加与子宫内膜癌和卵巢癌有关。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl Aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]

DPP3 基因产物(3)

mRNA Protein Name
NM_001256670.2 NP_001243599.1 dipeptidyl peptidase 3 isoform 2
NM_005700.5 NP_005691.2 dipeptidyl peptidase 3 isoform 1
NM_130443.4 NP_569710.2 dipeptidyl peptidase 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables dipeptidyl-peptidase activity IDA
IDA: 通过直接分析推断
9425109 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19615732 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
9425109 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in proteolysis IDA
IDA: 通过直接分析推断
9425109 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DPP3 蛋白结构

Peptidase_M49

Peptidase_M49: Peptidase family M49 (143 - 704)

  • 0
  • 200
  • 400
  • 600
  • 737 a.a.
蛋白主名 其他名称

dipeptidyl peptidase 3

DPP III

DPP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
种属内
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H Array
25416956
种属内
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H Array
32296183
种属内
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Validated Y2H
25416956
种属内
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Anti Tag CoIP
33961781
种属内
DPP3 Q9NY33 KEAP1 Homo sapiens Q14145
Y2H
21516116
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DPP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70112 Dipeptidyl peptidase 3/DPP3 Protein, Human (His) Q9NY33 (M1-A737) ≥95%

DPP3 抗体

目录号 产品名 应用 反应物种
HY-P86848 DPP3 Antibody (YA6541) WB, IHC-P, FC Human

关联疾病

疾病名称 别名
Cardiac Arrest

Cardiopulmonary Arrest

Circulatory Arrest

Heart Arrest
Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10

CMS10

Lgm

Myasthenia, Limb-Girdle, Familial

Myasthenia, Limb-Girdle, Familial, Formerly

Lgm, Formerly

Congenital Myasthenic Syndrome Type Ib, Formerly

Cms1b, Formerly

Cms Ib, Formerly

Myasthenic Myopathy, Formerly

Familial Limb-Girdle Myasthenia

Cms1b

Cms Ib

Congenital Myasthenic Syndrome Type 1b

Congenital Myasthenic Syndrome Type Ib

Myasthenic Myopathy

Myasthenic Syndrome, Congenital, Type 10

Congenital Myasthenic Syndrome Ib

Myopathy In Myasthenia Gravis
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P991050 Procizumab Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W074143 Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride 99.78% 否
HY-W127832 Ru(dpp)3(PF6)2 98.20% 否
HY-RS03962 DPP3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-135534 Lysine 4-nitroanilide / 否
HY-N15181 Fluostatin B Inhibitor / 否
HY-RS18349 Dpp3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24828 Dpp3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DPP3 VGNC VGNC:61603
Rattus norvegicus DPP3 RGD RGD:621127
Mus musculus DPP3 MGD MGI:1922471
Canis familiaris DPP3 VGNC VGNC:40073
Bos taurus DPP3 VGNC VGNC:28187
Others DPP3 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z