1. Gene
  2. TRIB1 - tribbles pseudokinase 1 Gene

TRIB1 - tribbles pseudokinase 1 Gene

中文名称:tribbles 假激酶 1

种属: Homo sapiens

同用名: C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1

基因 ID: 10221 | 基因类型: protein coding

关于 TRIB1

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:125,430,358-125,438,403 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues.

功能概要

启用丝裂原活化蛋白激酶激酶结合活性和蛋白激酶抑制剂活性。涉及几个进程,包括 JNK 级联;脂多糖介导的信号通路的负调控;和蛋白激酶活性的调节。位于细胞质和细胞核中。 [由基因组资源联盟提供,2022 年 4 月]

Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIB1 基因产物(2)

mRNA Protein Name
NM_001282985.2 NP_001269914.1 tribbles homolog 1 isoform 2
NM_025195.4 NP_079471.1 tribbles homolog 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
17724128 GOA
enables mitogen-activated protein kinase kinase binding IDA
IDA: 通过直接分析推断
15299019 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25852190 GOA
enables protein kinase inhibitor activity IMP
IMP: 通过突变表型推断
15299019 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17452330 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17452330 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIB1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (136 - 338)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
蛋白主名 其他名称

tribbles homolog 1

G-protein-coupled receptor induced protein

TRIB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIB1 Q96RU8 STK40 Homo sapiens Q8N2I9 32707033
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia

Familial Hypobetalipoproteinemia 1

Familial Hypobetalipoproteinemia

FHBL1

Hypobetalipoproteinemia, Familial

Fhbl

Acanthocytosis With Hypobetalipoproteinemia

Hypobetalipoproteinemias

Hypobetalipoproteinemia, Normotriglyceridemic

Hypo-Beta-Lipoproteinemia

Hypobetalipoprotéinemia, Familial

Normotriglyceridemic Hypobetalipoproteinemia

Hypobetalipoproteinemia, Familial, Type 1

Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V

Hyperchylomicronemia, Late-Onset

Familial Type 5 Hyperlipoproteinemia

Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial

Hyperlipidemia, Type V

Hyperlipemia, Mixed

Hyperlipemia, Combined Fat And Carbohydrate-Induced

Familial Hyperlipoproteinemia Type V

Fredrickson Type V Lipaemia

Hyperlipoproteinemia Type 5

Hyperchylomicronemia Late Onset

Hyperlipemia Combined Fat And Carbohydrate-Induced

Hyperlipemia Mixed

Hyperlipidemia Type V

Mixed Hyperlipemia

Type V Hyperlipoproteinemia

Hyperlipoproteinemia 5

HLPP5

Hyperlipidemia, Familial Combined

Mixed Hyperlipidemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TRIB1 MGD MGI:2443397
Rattus norvegicus TRIB1 RGD RGD:621596
Bos taurus TRIB1 VGNC VGNC:36308
Macaca mulatta TRIB1 VGNC VGNC:79056
Felis catus TRIB1 VGNC VGNC:66527
Canis familiaris TRIB1 VGNC VGNC:55007
Others TRIB1 NCBI