2. Gene
  3. Srsf1 - serine and arginine-rich splicing factor 1 Gene

Srsf1 - serine and arginine-rich splicing factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Asf; Sf2; Sfrs1; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik

基因 ID: 110809 | 基因类型: protein coding

关于 Srsf1

功能概要

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Srsf1 基因产物(2)

mRNA Protein Name
NM_001078167.2 NP_001071635.1 serine/arginine-rich splicing factor 1 isoform 2
NM_173374.4 NP_775550.2 serine/arginine-rich splicing factor 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RS domain binding IPI
IPI: 通过物理相互作用推断
15798186 MGI
enables mRNA binding IMP
IMP: 通过突变表型推断
21822258 MGI
enables molecular function regulator activity IDA
IDA: 通过直接分析推断
21822258 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20477871 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within RNA splicing IDA
IDA: 通过直接分析推断
15798186 MGI
acts upstream of or within RNA splicing IGI
IGI: 通过遗传相互作用推断
15652482 MGI
acts upstream of or within cardiac muscle contraction IGI
IGI: 通过遗传相互作用推断
15652482 MGI
involved in cellular response to interleukin-17 IDA
IDA: 通过直接分析推断
29563620 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
15652482 MGI
involved in interleukin-17-mediated signaling pathway IDA
IDA: 通过直接分析推断
21822258 MGI
involved in interleukin-17-mediated signaling pathway IMP
IMP: 通过突变表型推断
21822258 MGI
involved in mRNA stabilization IDA
IDA: 通过直接分析推断
21822258 MGI
involved in mRNA stabilization IMP
IMP: 通过突变表型推断
21822258 MGI
involved in protein localization to P-body IDA
IDA: 通过直接分析推断
29563620 MGI
involved in protein localization to nucleus IDA
IDA: 通过直接分析推断
29563620 MGI
involved in regulation of RNA splicing IMP
IMP: 通过突变表型推断
28785060 MGI
involved in signal transduction involved in regulation of gene expression IDA
IDA: 通过直接分析推断
21822258 MGI
involved in signal transduction involved in regulation of gene expression IMP
IMP: 通过突变表型推断
21822258 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear speck IDA
IDA: 通过直接分析推断
20729808 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15615787 MGI
is active in nucleus IPI
IPI: 通过物理相互作用推断
29563620 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/arginine-rich splicing factor 1

ASF/SF2

pre-mRNA-splicing factor SRp30a

splicing factor, arginine/serine-rich 1 (ASF/SF2)

Srsf1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Srsf1 Q6PDM2 Polr2a Mus musculus P08775
Anti Tag CoIP
23663783
种属内
Srsf1 Q6PDM2 Traf5 Mus musculus P70191
Anti Bait CoIP
21822258
种属内
Srsf1 Q6PDM2 Hexim1 Mus musculus Q8R409
Anti Tag CoIP
23663783
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-117661 SPHINX31 Inhibitor 98.84% 否
HY-170935 SRSF1-IN-1 Inhibitor / 否
HY-RS13790 SRSF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS17174 Srsf1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23624 Srsf1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Srsf1 NCBI NCBI:6426
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