2. Gene
  3. NCF1 - Ncf1 neutrophil cytosolic factor 1 Gene

NCF1 - Ncf1 neutrophil cytosolic factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Ncf-1; p47phox

基因 ID: 114553 | 基因类型: protein coding

关于 NCF1

功能概要

Enables superoxide-generating NADPH Oxidase activator activity. Involved in several processes, including Reactive Oxygen Species biosynthetic process; regulation of respiratory burst involved in inflammatory response; and respiratory burst. Located in several cellular components, including Golgi apparatus; neuronal cell body; and rough endoplasmic reticulum. Part of NADPH Oxidase complex. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1). [provided by Alliance of Genome Resources, Apr 2022]

NCF1 基因产物(1)

mRNA Protein Name
NM_053734.2 NP_446186.2 neutrophil cytosolic factor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables superoxide-generating NADPH oxidase activator activity IDA
IDA: 通过直接分析推断
16040349 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
25512346 RGD
involved in cellular response to testosterone stimulus IEP
IEP: 通过表达模式推断
25512346 RGD
involved in reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
21275845 RGD
involved in regulation of respiratory burst involved in inflammatory response IMP
IMP: 通过突变表型推断
21275845 RGD
involved in respiratory burst IMP
IMP: 通过突变表型推断
12461526 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NADPH oxidase complex IDA
IDA: 通过直接分析推断
12241540 RGD
located in cytosol IDA
IDA: 通过直接分析推断
24445059 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15804439 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15804439 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
24445059 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neutrophil cytosolic factor 1

neutrophil cytosol factor 1

neutrophil cytosol factor 1-like

phagocyte oxidase 47 kDa

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09077 NCF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20305 Ncf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26813 Ncf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens NCF1 NCBI NCBI:653361
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