2. Gene
  3. GRIN3B - glutamate ionotropic receptor NMDA type subunit 3B Gene

GRIN3B - glutamate ionotropic receptor NMDA type subunit 3B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷氨酸离子型受体 NMDA 型亚基 3B

种属: Homo sapiens

同用名: NR3B; GluN3B

基因 ID: 116444 | 基因类型: protein coding

关于 GRIN3B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,000,419-1,009,732 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 17 paralogues. Ubiquitous expression in spleen (RPKM 1.5), fat (RPKM 1.0) and 21 other tissues.

功能概要

该基因编码的蛋白质是 N-甲基-D-天冬氨酸 (NMDA) 受体的一个亚基。编码的蛋白质主要存在于运动神经元中，在那里它与 GRIN1 形成异四聚体以产生兴奋性甘氨酸受体。该基因的变异被认为与精神分裂症有关。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]

GRIN3B 基因产物(1)

mRNA Protein Name
NM_138690.3 NP_619635.1 glutamate receptor ionotropic, NMDA 3B precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: 通过直接分析推断
22564863 GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: 通过突变表型推断
22564863 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GRIN3B 蛋白结构

SBP_bac_3

SBP_bac_3: Bacterial extracellular solute-binding proteins, family 3 (478 - 809)

Lig_chan

Lig_chan: Ligand-gated ion channel (575 - 842)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1043 a.a.
蛋白主名 其他名称

glutamate receptor ionotropic, NMDA 3B

N-methyl-D-aspartate receptor subtype 3B

关联疾病

疾病名称 别名
Depersonalization Disorder

Neurotic Derealization

Depersonalization

Depersonalization/Derealization Disorder

Depersonalisation-Derealization Syndrome

Depersonalisation Disorder

Depersonalisation Neurosis

Depersonalisation Syndrome

Feeling Of Unreality

Feels Own Self Is Unreal

Neurotic State With Depersonalisation

Neurotic State With Depersonalization Episode
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Dissociative Disorder

Dissociative Disorders

Dissociative Disease

Dissociative Reaction
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
West Syndrome

Infantile Spasms

Infantile Spasms Syndrome

Infantile Spasm

X-Linked Infantile Spasm Syndrome

X-Linked Infantile Spasms

Epileptic Encephalopathy, Early Infantile, 1

Is

Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg

West'S Syndrome

Spasms, Infantile

Is -[Infantile Spasm]

Salaam Spasm

Salaam Tic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05807 GRIN3B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GRIN3B RGD RGD:621705
Felis catus GRIN3B VGNC VGNC:80056
Bos taurus GRIN3B VGNC VGNC:55211
Mus musculus GRIN3B MGD MGI:2150393
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