Akt2 - thymoma viral proto-oncogene 2 Gene

中文名称：胸腺瘤病毒原癌基因2

种属: Mus musculus

同用名: PKB; PKBbeta; 2410016A19Rik

关于 Akt2

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与多个过程，包括细胞对胰岛素刺激的反应；细胞内蛋白质跨膜转运；和运输的积极监管。在上游或内部对蛋白质定位到细胞核产生负面影响。作用于多个过程的上游或内部，包括 GTPase 活性的激活；细胞对高光强度的反应；和周围神经系统髓鞘维护。位于细胞皮质和皱褶膜。以多种结构表达，包括棕色脂肪；中枢神经系统;泌尿生殖系统；视网膜；和脾脏。用于研究多囊卵巢综合征和 2 型糖尿病。该基因的人类直系同源物与葡萄糖代谢疾病有关（多个）；高级别神经胶质瘤；伴有偏侧肥大的低胰岛素血症；和生殖器官癌（多发性）。与人类 AKT2（AKT 丝氨酸/苏氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to Insulin stimulus; intracellular protein transmembrane transport; and positive regulation of transport. Acts upstream of or within with a negative effect on protein localization to nucleus. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and peripheral nervous system myelin maintenance. Located in cell cortex and ruffle membrane. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; retina; and spleen. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; hypoinsulinemic hypoglycemia with hemihypertrophy; and reproductive organ Cancer (multiple). Orthologous to human Akt2 (Akt serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]