Atg5 - autophagy related 5 Gene

种属: Mus musculus

同用名: Apg5l; Atg5l; Paddy; 2010107M05Rik; 3110067M24Rik

基因 ID: 11793 | 基因类型: protein coding

关于 Atg5

功能概要

The protein encoded by this gene, in combination with Autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate Antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and Apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Atg5 基因产物(3)

mRNA	Protein	Name
NM_001314013.1	NP_001300942.1	autophagy protein 5 isoform 2
NM_001358596.1	NP_001345525.1	autophagy protein 5 isoform 3
NM_053069.6	NP_444299.1	autophagy protein 5 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11266458	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in aggrephagy	IMP IMP: 通过突变表型推断	22982048	MGI
acts upstream of or within antigen processing and presentation of endogenous antigen	IGI IGI: 通过遗传相互作用推断	23382543	MGI
acts upstream of or within antigen processing and presentation of endogenous antigen	IMP IMP: 通过突变表型推断	23382543	MGI
acts upstream of apoptotic process	IMP IMP: 通过突变表型推断	17450150	MGI
acts upstream of or within autophagosome assembly	IMP IMP: 通过突变表型推断	23704209	MGI
involved in autophagosome assembly	IMP IMP: 通过突变表型推断	11266458	MGI
involved in autophagy	IMP IMP: 通过突变表型推断	11266458	MGI
involved in axonal transport	IDA IDA: 通过直接分析推断	32210230	MGI
involved in axonal transport	IEP IEP: 通过表达模式推断	32210230	MGI
involved in axonal transport	IMP IMP: 通过突变表型推断	32210230	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: 通过突变表型推断	17450150	MGI
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: 通过突变表型推断	17450150	MGI
involved in cellular response to nitrosative stress	IMP IMP: 通过突变表型推断	23878245	MGI
acts upstream of or within cellular response to starvation	IMP IMP: 通过突变表型推断	22496425	MGI
acts upstream of positive effect chromatin organization	IMP IMP: 通过突变表型推断	23863932	MGI
acts upstream of or within defense response to virus	IMP IMP: 通过突变表型推断	26764600	MGI
acts upstream of establishment of localization in cell	IMP IMP: 通过突变表型推断	24185898	MGI
acts upstream of or within heart contraction	IMP IMP: 通过突变表型推断	17450150	MGI
acts upstream of or within innate immune response	IMP IMP: 通过突变表型推断	26764600	MGI
acts upstream of or within macroautophagy	IMP IMP: 通过突变表型推断	20453062	MGI
involved in macroautophagy	IMP IMP: 通过突变表型推断	11266458	MGI
acts upstream of mucus secretion	IMP IMP: 通过突变表型推断	24185898	MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process	IMP IMP: 通过突变表型推断	17450150	MGI
involved in negative regulation of defense response to virus	IDA IDA: 通过直接分析推断	17709747	MGI
involved in negative regulation of innate immune response	IDA IDA: 通过直接分析推断	17709747	MGI
acts upstream of or within negative regulation of phagocytosis	IMP IMP: 通过突变表型推断	24035364	MGI
acts upstream of or within negative regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	17450150	MGI
involved in negative regulation of type I interferon production	IDA IDA: 通过直接分析推断	17709747	MGI
acts upstream of or within negative stranded viral RNA replication	IMP IMP: 通过突变表型推断	24550300	MGI
acts upstream of or within negative thymic T cell selection	IGI IGI: 通过遗传相互作用推断	23382543	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: 通过突变表型推断	23382543	MGI
acts upstream of or within otolith development	IMP IMP: 通过突变表型推断	20577052	MGI
acts upstream of or within positive regulation of mucus secretion	IMP IMP: 通过突变表型推断	24185898	MGI
involved in post-translational protein modification	IDA IDA: 通过直接分析推断	11266458	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	35115539	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: 通过突变表型推断	35115539	MGI
acts upstream of or within protein lipidation involved in autophagosome assembly	IMP IMP: 通过突变表型推断	23918802	MGI
acts upstream of protein ubiquitination	IMP IMP: 通过突变表型推断	17450150	MGI
involved in regulation of cilium assembly	IMP IMP: 通过突变表型推断	24089205	MGI
acts upstream of or within regulation of cytokine production involved in immune response	IMP IMP: 通过突变表型推断	22710871	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: 通过直接分析推断	36217825	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: 通过突变表型推断	36217825	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IMP IMP: 通过突变表型推断	24185898	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IMP IMP: 通过突变表型推断	24185898	MGI
acts upstream of or within response to fungus	IMP IMP: 通过突变表型推断	22710871	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: 通过突变表型推断	17450150	MGI
acts upstream of or within vasodilation	IMP IMP: 通过突变表型推断	17450150	MGI
acts upstream of or within ventricular cardiac muscle cell development	IMP IMP: 通过突变表型推断	17450150	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Atg12-Atg5-Atg16 complex	IDA IDA: 通过直接分析推断	12665549	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: 通过直接分析推断	35115539	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: 通过突变表型推断	35115539	MGI
located in autophagosome	IDA IDA: 通过直接分析推断	11266458	MGI
located in axoneme	IDA IDA: 通过直接分析推断	24089209	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	11266458	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	32210230	MGI
is active in glutamatergic synapse	IEP IEP: 通过表达模式推断	32210230	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	32210230	MGI
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: 通过直接分析推断	23455425	MGI
located in phagophore assembly site membrane	IDA IDA: 通过直接分析推断	11266458	MGI
part of transferase complex	IDA IDA: 通过直接分析推断	20723759	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

autophagy protein 5

Atg5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Atg5	Q99J83	Atg12	Mus musculus	Q9CQY1	Anti Tag CoIP	12665549
种属内	Atg5	Q99J83	Atg12	Mus musculus	Q9CQY1	Anti Tag CoIP	20723759

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	是否罕见病
HY-W018791	Bifendate		99.91%	否
HY-N0538	Xylitol		≥98.0%	是

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-151914	Antitumor agent-82	Inducer	/	否
HY-157548	Antitumor agent-133	Inducer	/	否
HY-167843	Alborixin	Inhibitor	/	否
HY-170594	Antitumor agent-192	Inducer	/	否
HY-173133	Antitumor agent-199		/	否
HY-RS01152	ATG5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W768347	Xylitol-13C5		/	否
HY-RS17532	Atg5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS23989	Atg5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Atg5	NCBI	NCBI:9474

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Atg5 - autophagy related 5 Gene

关于 Atg5

功能概要

Atg5 基因产物(3)

Atg5 蛋白互作信息

直系同源

热门区域

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Atg5 - autophagy related 5 Gene

关于 Atg5

功能概要

Atg5 基因产物(3)

Atg5 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z