1. Gene
  2. Atg5 - autophagy related 5 Gene

Atg5 - autophagy related 5 Gene

种属: Mus musculus

同用名: Apg5l; Atg5l; Paddy; 2010107M05Rik; 3110067M24Rik

基因 ID: 11793 | 基因类型: protein coding

关于 Atg5

功能概要

The protein encoded by this gene, in combination with Autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate Antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and Apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Atg5 基因产物(3)

mRNA Protein Name
NM_001314013.1 NP_001300942.1 autophagy protein 5 isoform 2
NM_001358596.1 NP_001345525.1 autophagy protein 5 isoform 3
NM_053069.6 NP_444299.1 autophagy protein 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11266458 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aggrephagy IMP
IMP: 通过突变表型推断
22982048 MGI
acts upstream of or within antigen processing and presentation of endogenous antigen IGI
IGI: 通过遗传相互作用推断
23382543 MGI
acts upstream of or within antigen processing and presentation of endogenous antigen IMP
IMP: 通过突变表型推断
23382543 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
17450150 MGI
acts upstream of or within autophagosome assembly IMP
IMP: 通过突变表型推断
23704209 MGI
involved in autophagosome assembly IMP
IMP: 通过突变表型推断
11266458 MGI
involved in autophagy IMP
IMP: 通过突变表型推断
11266458 MGI
involved in axonal transport IDA
IDA: 通过直接分析推断
32210230 MGI
involved in axonal transport IEP
IEP: 通过表达模式推断
32210230 MGI
involved in axonal transport IMP
IMP: 通过突变表型推断
32210230 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: 通过突变表型推断
17450150 MGI
acts upstream of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
17450150 MGI
involved in cellular response to nitrosative stress IMP
IMP: 通过突变表型推断
23878245 MGI
acts upstream of or within cellular response to starvation IMP
IMP: 通过突变表型推断
22496425 MGI
acts upstream of positive effect chromatin organization IMP
IMP: 通过突变表型推断
23863932 MGI
acts upstream of or within defense response to virus IMP
IMP: 通过突变表型推断
26764600 MGI
acts upstream of establishment of localization in cell IMP
IMP: 通过突变表型推断
24185898 MGI
acts upstream of or within heart contraction IMP
IMP: 通过突变表型推断
17450150 MGI
acts upstream of or within innate immune response IMP
IMP: 通过突变表型推断
26764600 MGI
acts upstream of or within macroautophagy IMP
IMP: 通过突变表型推断
20453062 MGI
involved in macroautophagy IMP
IMP: 通过突变表型推断
11266458 MGI
acts upstream of mucus secretion IMP
IMP: 通过突变表型推断
24185898 MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
17450150 MGI
involved in negative regulation of defense response to virus IDA
IDA: 通过直接分析推断
17709747 MGI
involved in negative regulation of innate immune response IDA
IDA: 通过直接分析推断
17709747 MGI
acts upstream of or within negative regulation of phagocytosis IMP
IMP: 通过突变表型推断
24035364 MGI
acts upstream of or within negative regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
17450150 MGI
involved in negative regulation of type I interferon production IDA
IDA: 通过直接分析推断
17709747 MGI
acts upstream of or within negative stranded viral RNA replication IMP
IMP: 通过突变表型推断
24550300 MGI
acts upstream of or within negative thymic T cell selection IGI
IGI: 通过遗传相互作用推断
23382543 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: 通过突变表型推断
23382543 MGI
acts upstream of or within otolith development IMP
IMP: 通过突变表型推断
20577052 MGI
acts upstream of or within positive regulation of mucus secretion IMP
IMP: 通过突变表型推断
24185898 MGI
involved in post-translational protein modification IDA
IDA: 通过直接分析推断
11266458 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
35115539 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
35115539 MGI
acts upstream of or within protein lipidation involved in autophagosome assembly IMP
IMP: 通过突变表型推断
23918802 MGI
acts upstream of protein ubiquitination IMP
IMP: 通过突变表型推断
17450150 MGI
involved in regulation of cilium assembly IMP
IMP: 通过突变表型推断
24089205 MGI
acts upstream of or within regulation of cytokine production involved in immune response IMP
IMP: 通过突变表型推断
22710871 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
36217825 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: 通过突变表型推断
36217825 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
24185898 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
24185898 MGI
acts upstream of or within response to fungus IMP
IMP: 通过突变表型推断
22710871 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
17450150 MGI
acts upstream of or within vasodilation IMP
IMP: 通过突变表型推断
17450150 MGI
acts upstream of or within ventricular cardiac muscle cell development IMP
IMP: 通过突变表型推断
17450150 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Atg12-Atg5-Atg16 complex IDA
IDA: 通过直接分析推断
12665549 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
35115539 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
35115539 MGI
located in autophagosome IDA
IDA: 通过直接分析推断
11266458 MGI
located in axoneme IDA
IDA: 通过直接分析推断
24089209 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
11266458 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
32210230 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
32210230 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
32210230 MGI
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: 通过直接分析推断
23455425 MGI
located in phagophore assembly site membrane IDA
IDA: 通过直接分析推断
11266458 MGI
part of transferase complex IDA
IDA: 通过直接分析推断
20723759 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

autophagy protein 5

Atg5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Atg5 Q99J83 Atg12 Mus musculus Q9CQY1 12665549
种属内
Atg5 Q99J83 Atg12 Mus musculus Q9CQY1 20723759
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atg5 NCBI NCBI:9474