2. Gene
  3. Bmp2 - bone morphogenetic protein 2 Gene

Bmp2 - bone morphogenetic protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Bmp2a

基因 ID: 12156 | 基因类型: protein coding

关于 Bmp2

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. While a homozygous knockout mouse for this gene exhibits embryonic lethality, conditional knockout mice have defects in bone, cartilage and heart development. [provided by RefSeq, Jul 2016]

Bmp2 基因产物(1)

mRNA Protein Name
NM_007553.3 NP_031579.2 bone morphogenetic protein 2 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IMP
IMP: 通过突变表型推断
16730346 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12897139 MGI
enables protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
7798324 MGI
enables receptor ligand activity IDA
IDA: 通过直接分析推断
7798324 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
14623234 MGI
involved in BMP signaling pathway IDA
IDA: 通过直接分析推断
7798324 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
15975920 MGI
involved in BMP signaling pathway IMP
IMP: 通过突变表型推断
16730346 MGI
acts upstream of or within Notch signaling pathway IMP
IMP: 通过突变表型推断
16314491 MGI
acts upstream of ameloblast differentiation IDA
IDA: 通过直接分析推断
15525533 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
8898212 MGI
acts upstream of or within aortic valve development IMP
IMP: 通过突变表型推断
16730346 MGI
acts upstream of astrocyte differentiation IDA
IDA: 通过直接分析推断
15882580 MGI
acts upstream of astrocyte differentiation IGI
IGI: 通过遗传相互作用推断
15882580 MGI
involved in atrioventricular canal morphogenesis IMP
IMP: 通过突变表型推断
16730346 MGI
acts upstream of or within atrioventricular valve morphogenesis IMP
IMP: 通过突变表型推断
16314491 MGI
involved in bone development IMP
IMP: 通过突变表型推断
20551513 MGI
acts upstream of or within bone mineralization IDA
IDA: 通过直接分析推断
15657444 MGI
acts upstream of or within bone mineralization IGI
IGI: 通过遗传相互作用推断
19213727 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: 通过遗传相互作用推断
15925496 MGI
involved in cardiac atrium formation IMP
IMP: 通过突变表型推断
16730346 MGI
involved in cardiac jelly development IMP
IMP: 通过突变表型推断
16730346 MGI
involved in cardiac muscle cell differentiation IGI
IGI: 通过遗传相互作用推断
21145505 MGI
acts upstream of or within cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
16314491 MGI
acts upstream of or within cell fate commitment IMP
IMP: 通过突变表型推断
12421925 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
7848824 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
19103752 MGI
acts upstream of or within corticotropin hormone secreting cell differentiation IDA
IDA: 通过直接分析推断
9463347 MGI
acts upstream of or within embryo development IMP
IMP: 通过突变表型推断
8898212 MGI
acts upstream of or within embryonic heart tube anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
16314491 MGI
involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
16730346 MGI
acts upstream of or within endocardial cushion morphogenesis IMP
IMP: 通过突变表型推断
16314491 MGI
involved in endocardial cushion morphogenesis IMP
IMP: 通过突变表型推断
20890042 MGI
involved in epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
16730346 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
12397106 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
16314491 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
16314491 MGI
involved in inflammatory response IEP
IEP: 通过表达模式推断
12151307 MGI
acts upstream of or within inner ear development IDA
IDA: 通过直接分析推断
21795542 MGI
involved in mesenchymal cell proliferation involved in ureteric bud development IMP
IMP: 通过突变表型推断
15925496 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
15925496 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: 通过直接分析推断
15322112 MGI
involved in negative regulation of muscle cell differentiation IDA
IDA: 通过直接分析推断
7798324 MGI
involved in negative regulation of smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
18382765 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9585504 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16314491 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IDA
IDA: 通过直接分析推断
15525533 MGI
acts upstream of or within osteoblast differentiation IDA
IDA: 通过直接分析推断
19208758 MGI
involved in osteoblast differentiation IDA
IDA: 通过直接分析推断
7798324 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
15565649 MGI
acts upstream of or within pericardium development IMP
IMP: 通过突变表型推断
16314491 MGI
acts upstream of positive regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
18382765 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
14627707 MGI
involved in positive regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
19213727 MGI
acts upstream of or within positive regulation of astrocyte differentiation IDA
IDA: 通过直接分析推断
10486560 MGI
acts upstream of or within positive regulation of astrocyte differentiation IGI
IGI: 通过遗传相互作用推断
15882580 MGI
involved in positive regulation of bone mineralization IDA
IDA: 通过直接分析推断
20675382 MGI
acts upstream of or within positive regulation of cartilage development IDA
IDA: 通过直接分析推断
10684250 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
20675382 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IDA
IDA: 通过直接分析推断
15525533 MGI
acts upstream of or within positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
16314491 MGI
involved in positive regulation of extracellular matrix constituent secretion IMP
IMP: 通过突变表型推断
16730346 MGI
acts upstream of or within positive regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
15175325 MGI
acts upstream of positive regulation of gene expression IDA
IDA: 通过直接分析推断
18382765 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
21624478 MGI
acts upstream of positive regulation of gene expression IMP
IMP: 通过突变表型推断
16730346 MGI
involved in positive regulation of miRNA transcription IGI
IGI: 通过遗传相互作用推断
21145505 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
9786991 MGI
involved in positive regulation of odontoblast differentiation IMP
IMP: 通过突变表型推断
29148101 MGI
acts upstream of or within positive regulation of odontogenesis IDA
IDA: 通过直接分析推断
7848824 MGI
acts upstream of or within positive regulation of ossification IDA
IDA: 通过直接分析推断
15820682 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
15175325 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
20675382 MGI
involved in positive regulation of osteoblast proliferation IMP
IMP: 通过突变表型推断
20675382 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
1468569 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16314491 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20890042 MGI
acts upstream of or within protein destabilization IDA
IDA: 通过直接分析推断
15322112 MGI
acts upstream of or within protein destabilization IGI
IGI: 通过遗传相互作用推断
15322112 MGI
acts upstream of or within proteoglycan metabolic process IGI
IGI: 通过遗传相互作用推断
16935278 MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
9244299 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
20042692 MGI
acts upstream of or within telencephalon regionalization IGI
IGI: 通过遗传相互作用推断
11719201 MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation IDA
IDA: 通过直接分析推断
9463347 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10391928 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16314491 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular region IDA
IDA: 通过直接分析推断
21976273 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
15110716 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
7798324 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bone morphogenetic protein 2

bone morphogenetic protein 2A

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-100009 Ufenamate Inhibitor 99.89% 否
Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16712 LDN-214117 Inhibitor 99.92% 否
HY-136848 SM1-71 Inhibitor 96.09% 否
HY-N0316 Mollugin 99.48% 否
HY-N0265 Asperosaponin VI Inhibitor 98.73% 否
HY-P0254 Kisspeptin-10, human 99.68% 否
HY-N2375 L-Quebrachitol Activator ≥98.0% 否
HY-123940 SGC-AAK1-1 Inhibitor 98.93% 否
HY-P0254A Kisspeptin-10, human TFA 99.85% 否
HY-120179 LP-922761 99.73% 否
HY-P5832 BMP2-derived peptide Ligand 98.48% 否
HY-107245 Segetalin B 99.51% 否
HY-101290A BMT-090605 hydrochloride Inhibitor 98.76% 否
HY-108531A ER 50891 quarterhydrate Antagonist 99.86% 否
HY-N8920 Syringetin 99.42% 否
HY-108531 ER 50891 Antagonist 99.86% 否
HY-142042 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles Inhibitor 99.84% 否
HY-135871 BMT-124110 98.93% 否
HY-158203 BMP agonist 2 Agonist 99.26% 否
HY-N0946 (-)-Pinoresinol 4-O-glucoside Inhibitor ≥98.0% 否
HY-120179A LP-922761 hydrate ≥98.0% 否
HY-135871A BMT-124110 formic Inhibitor / 否
HY-101290 BMT-090605 Inhibitor 98.27% 否
HY-121025 BUR1 Inhibitor 99.65% 否
HY-N2682B Dehydrodiconiferyl alcohol Agonist / 否
HY-N8261 Amicoumacin B / 否
HY-RS01536 BMP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01537 BMP2K Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01553 Bmpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16626 Bmp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17130 Bmp2k Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23061 Bmp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23575 Bmp2k Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bmp2 NCBI NCBI:650
Rattus norvegicus Bmp2 NCBI NCBI:29373
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