Cd2ap - CD2-associated protein Gene

种属: Mus musculus

同用名: Mets1; METS-1

基因 ID: 12488 | 基因类型: protein coding

关于 Cd2ap

功能概要

This gene encodes a scaffolding molecule that regulates the actin Cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. The mouse genome contains at least two pseudogenes located on chromosomes 9 and 17. [provided by RefSeq, Jul 2008]

Cd2ap 基因产物(4)

mRNA	Protein	Name
NM_001410466.1	NP_001397395.1	CD2-associated protein isoform 2
NM_001410467.1	NP_001397396.1	CD2-associated protein isoform 3
NM_001410468.1	NP_001397397.1	CD2-associated protein isoform 4
NM_009847.4	NP_033977.3	CD2-associated protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin binding	IDA IDA: 通过直接分析推断	15956777	MGI
enables actin filament binding	IDA IDA: 通过直接分析推断	17606992	MGI
enables clathrin binding	IDA IDA: 通过直接分析推断	26546360	MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: 通过直接分析推断	27076424	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	10913159	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within D-glucose import	IMP IMP: 通过突变表型推断	26546360	MGI
acts upstream of or within ERK1 and ERK2 cascade	IGI IGI: 通过遗传相互作用推断	28878342	MGI
acts upstream of or within Rab protein signal transduction	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	14512504	MGI
acts upstream of or within actin filament polymerization	IMP IMP: 通过突变表型推断	24218450	MGI
acts upstream of or within adipose tissue development	IDA IDA: 通过直接分析推断	29729186	MGI
acts upstream of or within apoptotic process	IGI IGI: 通过遗传相互作用推断	28878342	MGI
acts upstream of or within apoptotic process	IMP IMP: 通过突变表型推断	14512504	MGI
acts upstream of or within cell differentiation	IGI IGI: 通过遗传相互作用推断	19013146	MGI
acts upstream of or within cell population proliferation	IMP IMP: 通过突变表型推断	19679673	MGI
acts upstream of or within cell-cell adhesion mediated by cadherin	IGI IGI: 通过遗传相互作用推断	19013146	MGI
acts upstream of or within cell-cell junction organization	IGI IGI: 通过遗传相互作用推断	19013146	MGI
acts upstream of or within cell-cell junction organization	IMP IMP: 通过突变表型推断	25968128	MGI
acts upstream of or within collateral sprouting	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within endothelium development	IMP IMP: 通过突变表型推断	25968128	MGI
acts upstream of or within filopodium assembly	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within gene expression	IGI IGI: 通过遗传相互作用推断	28878342	MGI
acts upstream of or within gene expression	IMP IMP: 通过突变表型推断	15213232	MGI
acts upstream of or within glomerulus development	IMP IMP: 通过突变表型推断	25968128	MGI
acts upstream of or within immunological synapse formation	IMP IMP: 通过突变表型推断	14512504	MGI
acts upstream of or within inflammatory response	IMP IMP: 通过突变表型推断	14512504	MGI
acts upstream of or within kidney development	IDA IDA: 通过直接分析推断	15213232	MGI
acts upstream of or within kidney development	IMP IMP: 通过突变表型推断	15213232	MGI
acts upstream of or within lipid metabolic process	IDA IDA: 通过直接分析推断	29729186	MGI
acts upstream of or within liver development	IDA IDA: 通过直接分析推断	29729186	MGI
acts upstream of or within localization of cell	IGI IGI: 通过遗传相互作用推断	19013146	MGI
acts upstream of or within lymph node development	IMP IMP: 通过突变表型推断	24218450	MGI
acts upstream of or within maintenance of blood-brain barrier	IMP IMP: 通过突变表型推断	26358779	MGI
acts upstream of or within male gonad development	IMP IMP: 通过突变表型推断	15213232	MGI
acts upstream of or within membrane organization	IMP IMP: 通过突变表型推断	25968128	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: 通过直接分析推断	18753381	MGI
acts upstream of or within negative regulation of transforming growth factor beta1 production	IGI IGI: 通过遗传相互作用推断	21911934	MGI
acts upstream of or within nerve growth factor signaling pathway	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within neuron projection development	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within neurotrophin TRK receptor signaling pathway	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within neurotrophin signaling pathway	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: 通过遗传相互作用推断	28878342	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	15213232	MGI
acts upstream of or within podocyte differentiation	IMP IMP: 通过突变表型推断	25968128	MGI
acts upstream of or within positive regulation of protein localization to nucleus	IGI IGI: 通过遗传相互作用推断	21911934	MGI
acts upstream of or within protein catabolic process	IDA IDA: 通过直接分析推断	18753381	MGI
acts upstream of or within protein catabolic process	IMP IMP: 通过突变表型推断	14512504	MGI
acts upstream of or within protein heterooligomerization	IDA IDA: 通过直接分析推断	17606992	MGI
acts upstream of or within protein phosphorylation	IMP IMP: 通过突变表型推断	14512504	MGI
acts upstream of or within protein secretion	IMP IMP: 通过突变表型推断	22809625	MGI
acts upstream of or within protein transport	IMP IMP: 通过突变表型推断	26546360	MGI
acts upstream of or within regulation of actin cytoskeleton organization	IGI IGI: 通过遗传相互作用推断	21911934	MGI
acts upstream of or within regulation of protein binding	IDA IDA: 通过直接分析推断	27076424	MGI
acts upstream of or within regulation of protein binding	IMP IMP: 通过突变表型推断	19679673	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within renal albumin absorption	IMP IMP: 通过突变表型推断	30612599	MGI
acts upstream of or within response to glial cell derived neurotrophic factor	IDA IDA: 通过直接分析推断	18753381	MGI
acts upstream of or within response to insulin	IMP IMP: 通过突变表型推断	26546360	MGI
acts upstream of or within response to oxidative stress	IMP IMP: 通过突变表型推断	28878342	MGI
acts upstream of or within response to transforming growth factor beta	IMP IMP: 通过突变表型推断	15213232	MGI
acts upstream of or within response to virus	IDA IDA: 通过直接分析推断	29729186	MGI
acts upstream of or within response to wounding	IMP IMP: 通过突变表型推断	27076424	MGI
acts upstream of or within stress-activated MAPK cascade	IMP IMP: 通过突变表型推断	15213232	MGI
involved in synapse organization	IDA IDA: 通过直接分析推断	31412248	MGI
involved in synapse organization	IEP IEP: 通过表达模式推断	31412248	MGI
involved in synapse organization	IMP IMP: 通过突变表型推断	31412248	MGI
acts upstream of transforming growth factor beta1 production	IGI IGI: 通过遗传相互作用推断	21911934	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in actin filament	IDA IDA: 通过直接分析推断	17606992	MGI
located in axon	IDA IDA: 通过直接分析推断	32552912	MGI
is active in cell periphery	IDA IDA: 通过直接分析推断	16501493	MGI
located in cell-cell junction	IDA IDA: 通过直接分析推断	23793062	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	10913159	MGI
located in dendrite	IDA IDA: 通过直接分析推断	32552912	MGI
is active in growth cone	IMP IMP: 通过突变表型推断	27076424	MGI
is active in late endosome	IDA IDA: 通过直接分析推断	15956777	MGI
is active in neuromuscular junction	IDA IDA: 通过直接分析推断	31412248	MGI
is active in neuromuscular junction	IEP IEP: 通过表达模式推断	31412248	MGI
is active in neuromuscular junction	IMP IMP: 通过突变表型推断	31412248	MGI
is active in neuron projection	IMP IMP: 通过突变表型推断	27076424	MGI
is active in nuclear envelope lumen	IDA IDA: 通过直接分析推断	26546360	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	15924139	MGI
is active in podosome	IDA IDA: 通过直接分析推断	17606992	MGI
part of protein-containing complex	IDA IDA: 通过直接分析推断	27076424	MGI
is active in slit diaphragm	IDA IDA: 通过直接分析推断	11733379	MGI
is active in trans-Golgi network membrane	IDA IDA: 通过直接分析推断	26546360	MGI
is active in vesicle	IDA IDA: 通过直接分析推断	15956777	MGI
located in vesicle	IDA IDA: 通过直接分析推断	32552912	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

CD2-associated protein

SH3 domain-containing adapter protein	SH3 domain-containing adaptor protein METS-1
mesenchyme to epithelium transition protein, SH3 domains	mesenchyme-to-epithelium transition protein with SH3 domains 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS21509	Cd2ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS02224	CD2AP Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28027	Cd2ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Cd2ap	NCBI	NCBI:23607

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Cd2ap - CD2-associated protein Gene

关于 Cd2ap

功能概要

Cd2ap 基因产物(4)

直系同源

热门区域

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Cd2ap - CD2-associated protein Gene

关于 Cd2ap

功能概要

Cd2ap 基因产物(4)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z