Cebpa - CCAAT/enhancer binding protein (C/EBP), alpha Gene

种属: Mus musculus

同用名: Cebp; CBF-A; C/ebpalpha

基因 ID: 12606 | 基因类型: protein coding

关于 Cebpa

功能概要

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014]

Cebpa 基因产物(5)

mRNA	Protein	Name
NM_001287514.1	NP_001274443.1	CCAAT/enhancer-binding protein alpha isoform c
NM_001287515.1	NP_001274444.1	CCAAT/enhancer-binding protein alpha isoform d
NM_001287521.1	NP_001274450.1	CCAAT/enhancer-binding protein alpha isoform b
NM_001287523.1	NP_001274452.1	CCAAT/enhancer-binding protein alpha isoform e
NM_007678.3	NP_031704.2	CCAAT/enhancer-binding protein alpha isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	10510303	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	10233885	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	17213233	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	10859308	MGI
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	17290224	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10233885	MGI
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	25921091	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	22780989	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	12821655	MGI
enables kinase binding	IPI IPI: 通过物理相互作用推断	15107404	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	10082561	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	11672531	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	18632661	MGI
enables transcription factor binding	IPI IPI: 通过物理相互作用推断	17090532	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within Notch signaling pathway	IDA IDA: 通过直接分析推断	25446530	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: 通过直接分析推断	18492766	MGI
acts upstream of cell population proliferation	IMP IMP: 通过突变表型推断	15073037	MGI
acts upstream of or within cellular response to lithium ion	IDA IDA: 通过直接分析推断	15673614	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: 通过直接分析推断	12055200	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	1618860	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: 通过突变表型推断	18974039	MGI
acts upstream of or within embryonic placenta development	IGI IGI: 通过遗传相互作用推断	15509779	MGI
involved in energy homeostasis	IDA IDA: 通过直接分析推断	36977414	MGI
acts upstream of or within epithelial cell maturation	IMP IMP: 通过突变表型推断	16467360	MGI
acts upstream of or within fat cell differentiation	IDA IDA: 通过直接分析推断	12037571	MGI
involved in fat cell differentiation	IDA IDA: 通过直接分析推断	11672531	MGI
involved in fat cell differentiation	IMP IMP: 通过突变表型推断	1935900	MGI
involved in glucose homeostasis	IMP IMP: 通过突变表型推断	8798745	MGI
involved in granulocyte differentiation	IDA IDA: 通过直接分析推断	11672531	MGI
involved in granulocyte differentiation	IMP IMP: 通过突变表型推断	15589173	MGI
acts upstream of hematopoietic stem cell proliferation	IMP IMP: 通过突变表型推断	15073037	MGI
acts upstream of or within inner ear development	IDA IDA: 通过直接分析推断	21795542	MGI
involved in lipid homeostasis	IMP IMP: 通过突变表型推断	17290224	MGI
acts upstream of or within liver development	IMP IMP: 通过突变表型推断	17021047	MGI
involved in liver development	IMP IMP: 通过突变表型推断	8798745	MGI
acts upstream of or within lung development	IMP IMP: 通过突变表型推断	16467360	MGI
involved in lung development	IMP IMP: 通过突变表型推断	8798745	MGI
acts upstream of or within macrophage differentiation	IMP IMP: 通过突变表型推断	15073037	MGI
acts upstream of or within mitochondrion organization	IMP IMP: 通过突变表型推断	11940593	MGI
involved in myeloid cell differentiation	IDA IDA: 通过直接分析推断	15664994	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11672531	MGI
involved in negative regulation of cell cycle	IDA IDA: 通过直接分析推断	15107404	MGI
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	11672531	MGI
acts upstream of or within negative regulation of hematopoietic stem cell proliferation	IMP IMP: 通过突变表型推断	15073037	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10859308	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17213233	MGI
acts upstream of or within positive regulation of fat cell differentiation	IDA IDA: 通过直接分析推断	10937998	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	16445384	MGI
involved in positive regulation of inflammatory response	IMP IMP: 通过突变表型推断	21131957	MGI
involved in positive regulation of macrophage activation	IMP IMP: 通过突变表型推断	21131957	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: 通过直接分析推断	15175325	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18632661	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10233885	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10075730	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: 通过突变表型推断	17021047	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18632661	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17090532	MGI
acts upstream of or within urea cycle	IDA IDA: 通过直接分析推断	17213233	MGI
acts upstream of or within white fat cell differentiation	IMP IMP: 通过突变表型推断	15130516	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in nucleus	IDA IDA: 通过直接分析推断	36977414	MGI
located in nucleus	IDA IDA: 通过直接分析推断	11672531	MGI
part of transcription regulator complex	IDA IDA: 通过直接分析推断	12861022	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

CCAAT/enhancer-binding protein alpha

C/EBP alpha

目录号	产品名	作用方式	纯度	Phase
HY-132607A	MTL-CEBPA sodium		94.63%	Phase 2
HY-132607	MTL-CEBPA		95.52%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-168483	FTO-IN-13		/	否
HY-RS02445	CEBPA Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18653	Cebpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS25139	Cebpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Cebpa	NCBI	NCBI:1050

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Cebpa - CCAAT/enhancer binding protein (C/EBP), alpha Gene

关于 Cebpa

功能概要

Cebpa 基因产物(5)

直系同源

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Cebpa - CCAAT/enhancer binding protein (C/EBP), alpha Gene

关于 Cebpa

功能概要

Cebpa 基因产物(5)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z