H1-8 - H1.8 linker histone Gene

中文名称：H1.8 接头组蛋白

种属: Homo sapiens

同用名: H1.8; H1oo; osH1; H1FOO

关于 H1-8

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。核小体由大约 146 bp 的 DNA 组成，包裹在由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成的组蛋白八聚体周围。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。编码的蛋白质是一种不依赖于复制的组蛋白，是组蛋白 H1 家族的成员。与大多数组蛋白基因不同，该基因包含内含子。相关的小鼠基因仅在卵母细胞中表达。[RefSeq 提供，2015 年 10 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]