1. Gene
  2. Dnase1 - deoxyribonuclease I Gene

Dnase1 - deoxyribonuclease I Gene

种属: Mus musculus

同用名: Dnl1; DNaseI

基因 ID: 13419 | 基因类型: protein coding

关于 Dnase1

功能概要

Enables deoxyribonuclease I activity. Involved in several processes, including DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in cytoplasmic vesicle and extracellular region. Predicted to be active in nucleus. Is expressed in jejunum; metanephros; and tongue. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Dnase1 基因产物(2)

mRNA Protein Name
NM_001357143.1 NP_001344072.1 deoxyribonuclease-1 precursor
NM_010061.5 NP_034191.3 deoxyribonuclease-1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deoxyribonuclease I activity IMP
IMP: 通过突变表型推断
15015938 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA catabolic process IDA
IDA: 通过直接分析推断
29191910 MGI
involved in neutrophil activation involved in immune response IDA
IDA: 通过直接分析推断
29191910 MGI
involved in regulation of acute inflammatory response IDA
IDA: 通过直接分析推断
29191910 MGI
involved in regulation of neutrophil mediated cytotoxicity IDA
IDA: 通过直接分析推断
29191910 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

deoxyribonuclease-1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dnase1 NCBI NCBI:1773