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  2. E2f1 - E2F transcription factor 1 Gene

E2f1 - E2F transcription factor 1 Gene

种属: Mus musculus

同用名: E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor

基因 ID: 13555 | 基因类型: protein coding

关于 E2f1

功能概要

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; and transcription, DNA-templated. Acts upstream of or within several processes, including anoikis; intrinsic apoptotic signaling pathway by p53 class mediator; and lens fiber cell apoptotic process. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

E2f1 基因产物(2)

mRNA Protein Name
NM_001291105.1 NP_001278034.1 transcription factor E2F1 isoform b precursor
NM_007891.5 NP_031917.1 transcription factor E2F1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity IDA
IDA: 通过直接分析推断
35263589 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
10779331 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10597240 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11672531 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
24014029 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription IDA
IDA: 通过直接分析推断
11672531 MGI
acts upstream of or within anoikis IDA
IDA: 通过直接分析推断
14667810 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
24726645 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
15525772 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: 通过直接分析推断
11095619 MGI
acts upstream of or within lens fiber cell apoptotic process IDA
IDA: 通过直接分析推断
11095619 MGI
involved in negative regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
11672531 MGI
involved in negative regulation of fat cell proliferation IMP
IMP: 通过突变表型推断
20176812 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11331592 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11004506 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
7797074 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11071387 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: 通过直接分析推断
11095619 MGI
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
35263589 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
12007404 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
8918469 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
10082561 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8918469 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
10082561 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

transcription factor E2F1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens E2f1 NCBI NCBI:1869