CREBL2 - cAMP responsive element binding protein like 2 Gene

中文名称：cAMP 反应元件结合蛋白样 2

种属: Homo sapiens

关于 CREBL2

功能概要

cAMP 反应元件 (CRE) -binding protein-like-2 (CREBL2) 是在一项搜索中发现的，该基因位于 12p13 染色体上一个常见缺失区域，两侧是 ETV6 和 CDKN1B 基因，通常与造血系统恶性肿瘤以及乳腺癌相关非小细胞肺癌和卵巢癌。 CREBL2 在编码 CREB 的 bZip 结构域的 48 个碱基长区域与 CRE 结合蛋白 (CREB) 具有 41% 的同一性。 bZip 结构域由大约 30 个氨基酸组成，这些氨基酸富含参与 DNA 结合的碱性残基，随后是参与蛋白质二聚化的亮氨酸拉链基序。这表明 CREBL2 编码的蛋白质具有 DNA 结合能力。 CREBL2 缺失在恶性肿瘤中的出现提示 CREBL2 可能作为抑癌基因发挥作用。[RefSeq 提供，2008 年 7 月]

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 Amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]