1. Gene
  2. APOBEC3D - apolipoprotein B mRNA editing enzyme catalytic subunit 3D Gene

APOBEC3D - apolipoprotein B mRNA editing enzyme catalytic subunit 3D Gene

中文名称:载脂蛋白 B mRNA 编辑酶催化亚基 3D

种属: Homo sapiens

同用名: A3D; A3DE; ARP6; APOBEC3E; APOBEC3DE

基因 ID: 140564 | 基因类型: protein coding

关于 APOBEC3D

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,021,127-39,033,277 (from NCBI)

This gene has 3 transcripts (splice variants), 48 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 5.2), spleen (RPKM 4.6) and 22 other tissues.

功能概要

该基因是胞苷脱氨酶基因家族的成员。它是在一个簇中发现的一组相关基因之一,被认为是由 22 号染色体上的基因复制引起的。该簇的成员编码的蛋白质在结构和功能上与 C 到 U RNA 编辑胞苷脱氨酶 APOBEC1 相关,并抑制通过使新生逆转录病毒 cDNA 中的胞嘧啶残基脱氨基来去除逆转录病毒,例如 HIV。[RefSeq 提供,2008 年 7 月]

This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]

APOBEC3D 基因产物(2)

mRNA Protein Name
NM_001363781.1 NP_001350710.1 DNA dC->dU-editing enzyme APOBEC-3D isoform 2
NM_152426.4 NP_689639.2 DNA dC->dU-editing enzyme APOBEC-3D isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA cytosine deamination IDA
IDA: 通过直接分析推断
21835787 GOA
involved in clearance of foreign intracellular DNA IDA
IDA: 通过直接分析推断
20062055 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
21835787 GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
IDA: 通过直接分析推断
21835787 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
22915799 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21835787 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

APOBEC3D 蛋白结构

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (68 - 197)

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (216 - 384)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

DNA dC->dU-editing enzyme APOBEC-3D

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D

关联疾病

疾病名称 别名
Brachydactyly, Type A3

Brachydactyly Type A3

BDA3

Brachydactyly-Clinodactyly

Brachymesophalangy V

Brachymesophalangy 5

Brachydactyly Clinodactyly

Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus APOBEC3D MGD MGI:1933111