2. Gene
  3. Hap1 - huntingtin-associated protein 1 Gene

Hap1 - huntingtin-associated protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HAP-1

基因 ID: 15114 | 基因类型: protein coding

关于 Hap1

功能概要

The protein encoded by this gene was first identified as a neuronal protein that binds the HD protein Huntingtin. The protein also interacts with Kinesin light chain, 14-3-3 proteins, and Abelson helper integration site 1 protein. The protein is involved in intracellular trafficking of vesicles and organelles, and lack of the protein results in neuronal death resembling the hypothalamic degeneration that occurs in Huntington's disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Hap1 基因产物(3)

mRNA Protein Name
NM_001359052.1 NP_001345981.1 huntingtin-associated protein 1 isoform C
NM_010404.3 NP_034534.1 huntingtin-associated protein 1 isoform A
NM_177981.2 NP_817090.1 huntingtin-associated protein 1 isoform B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9599014 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anterograde axonal transport IMP
IMP: 通过突变表型推断
24355921 MGI
involved in cerebellum development IMP
IMP: 通过突变表型推断
18636121 MGI
involved in hypothalamus cell differentiation IMP
IMP: 通过突变表型推断
24355921 MGI
involved in neurogenesis IMP
IMP: 通过突变表型推断
18636121 MGI
involved in neurotrophin TRK receptor signaling pathway IMP
IMP: 通过突变表型推断
24355921 MGI
involved in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IMP
IMP: 通过突变表型推断
15379999 MGI
involved in positive regulation of neurogenesis IMP
IMP: 通过突变表型推断
24355921 MGI
acts upstream of or within positive regulation of non-motile cilium assembly IMP
IMP: 通过突变表型推断
21985783 MGI
involved in positive regulation of non-motile cilium assembly IMP
IMP: 通过突变表型推断
21985783 MGI
involved in regulation of exocytosis IMP
IMP: 通过突变表型推断
24366265 MGI
involved in regulation of organelle transport along microtubule IMP
IMP: 通过突变表型推断
24453320 MGI
acts upstream of or within vesicle transport along microtubule IMP
IMP: 通过突变表型推断
15242649 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in autophagosome IDA
IDA: 通过直接分析推断
24453320 MGI
located in centriole IDA
IDA: 通过直接分析推断
21985783 MGI
located in centrosome IDA
IDA: 通过直接分析推断
21985783 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
15242649 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

huntingtin-associated protein 1

Hap1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Hap1 O35668 Ahi1 Mus musculus Q8K3E5
Anti Bait CoIP
21146532
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150221 DB008 Inhibitor 98.78% 否
HY-RS00815 APEX1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-173281 MAT2A-IN-24 Inhibitor / 否
HY-174296 TMX-4102 / 否
HY-174866 BT-O2C Inhibitor / 否
HY-P4096 HAP-1 99.08% 否
HY-RS06000 HAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS17886 Hap1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS21480 Apex1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS24355 Hap1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hap1 NCBI NCBI:9001
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