2. Gene
  3. Hells - helicase, lymphoid specific Gene

Hells - helicase, lymphoid specific Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: LSH; Lysh; PASG; YFK8; E130115I21Rik

基因 ID: 15201 | 基因类型: protein coding

关于 Hells

功能概要

Enables chromatin binding activity. Involved in DNA methylation-dependent heterochromatin assembly; maintenance of DNA methylation; and pericentric heterochromatin assembly. Acts upstream of or within several processes, including DNA methylation; cellular response to leukemia inhibitory factor; and negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including central nervous system; gut; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Apr 2022]

Hells 基因产物(1)

mRNA Protein Name
NM_008234.3 NP_032260.2 lymphocyte-specific helicase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
15448183 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16395332 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA methylation-dependent heterochromatin formation IMP
IMP: 通过突变表型推断
15647320 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
11325543 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within chromatin remodeling IMP
IMP: 通过突变表型推断
11711429 MGI
acts upstream of or within chromosomal DNA methylation maintenance following DNA replication IMP
IMP: 通过突变表型推断
11711429 MGI
acts upstream of or within heterochromatin formation IMP
IMP: 通过突变表型推断
15448183 MGI
involved in kidney development IMP
IMP: 通过突变表型推断
11325543 MGI
involved in lymphocyte proliferation IEP
IEP: 通过表达模式推断
10781083 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
11325543 MGI
involved in negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: 通过突变表型推断
15105378 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
11325543 MGI
involved in pericentric heterochromatin formation IMP
IMP: 通过突变表型推断
14612388 MGI
acts upstream of or within urogenital system development IMP
IMP: 通过突变表型推断
11325543 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
14612388 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11555636 MGI
located in pericentric heterochromatin IDA
IDA: 通过直接分析推断
14612388 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

lymphocyte-specific helicase

proliferation-associated SNF2-like protein

Hells 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Hells Q60848 Cbx2 Mus musculus P30658
Anti Bait CoIP
17726103
种属内
Hells Q60848 Dnmt3b Mus musculus O88509
Anti Bait CoIP
16395332
种属内
Hells Q60848 Pcgf2 Mus musculus P23798
Anti Bait CoIP
17726103
种属内
Hells Q60848 Bmi1 Mus musculus P25916
Anti Bait CoIP
17726103
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06115 HELLS Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20035 Hells Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26538 Hells Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hells NCBI NCBI:3070
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