1. Gene
  2. FAAH2 - fatty acid amide hydrolase 2 Gene

FAAH2 - fatty acid amide hydrolase 2 Gene

中文名称:脂肪酸酰胺水解酶 2

种属: Homo sapiens

同用名: AMDD

基因 ID: 158584 | 基因类型: protein coding

关于 FAAH2

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:57,121,591-57,489,196 (from NCBI)

This gene has 3 transcripts (splice variants), 160 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 2.5), skin (RPKM 1.5) and 24 other tissues.

功能概要

该基因编码一种脂肪酸酰胺水解酶,该酶与酰胺酶特征酶家族共享一个保守的蛋白质基序。编码的酶能够催化广泛的生物活性脂质的水解,包括来自三大类脂肪酸酰胺的那些; N-酰基乙醇胺、脂肪酸伯酰胺和 N-酰基氨基酸。该酶偏爱单不饱和酰基链作为底物。交替剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2017 年 7 月]

This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of Enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl Amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

FAAH2 基因产物(3)

mRNA Protein Name
NM_001353840.1 NP_001340769.1 fatty-acid amide hydrolase 2 isoform 2
NM_001353841.1 NP_001340770.1 fatty-acid amide hydrolase 2 isoform 3
NM_174912.4 NP_777572.2 fatty-acid amide hydrolase 2 isoform 1

FAAH2 蛋白结构

Amidase

Amidase: Amidase (69 - 513)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 532 a.a.
蛋白主名 其他名称

fatty-acid amide hydrolase 2

amidase domain containing

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 28

DEE28

Epileptic Encephalopathy, Early Infantile, 28

Eiee28

Developmental And Epileptic Encephalopathy, 28

Early Infantile Epileptic Encephalopathy 28

Encephalopathy, Epileptic, Early Infantile, Type 28

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma