2. Gene
  3. Itga4 - integrin alpha 4 Gene

Itga4 - integrin alpha 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CD49D; Itga4B

基因 ID: 16401 | 基因类型: protein coding

关于 Itga4

功能概要

Enables fibronectin binding activity. Acts upstream of or within several processes, including chorio-allantoic fusion; face development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic Cancer. Orthologous to human ITGA4 (Integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Itga4 基因产物(1)

mRNA Protein Name
NM_010576.4 NP_034706.3 integrin alpha-4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibronectin binding IMP
IMP: 通过突变表型推断
8145052 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell migration IMP
IMP: 通过突变表型推断
23661644 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: 通过突变表型推断
16529735 MGI
acts upstream of or within cell adhesion IMP
IMP: 通过突变表型推断
12021259 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
12021259 MGI
acts upstream of or within chorio-allantoic fusion IMP
IMP: 通过突变表型推断
7539359 MGI
acts upstream of or within face development IMP
IMP: 通过突变表型推断
7539359 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
7539359 MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: 通过突变表型推断
8145052 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: 通过突变表型推断
8562500 MGI
acts upstream of or within pericyte cell migration IMP
IMP: 通过突变表型推断
16529735 MGI
acts upstream of or within vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
16529735 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23610556 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
7539359 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin alpha-4

CD49 antigen-like family member D

LPAM subunit alpha

VLA-4 receptor, alpha 4 subunit

VLA-4 subunit alpha

integrin alpha-IV

integrin alpha4B

lymphocyte Peyer patch adhesion molecules subunit alpha

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99184 Abrilumab 98.35% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06951 ITGA4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17832 Itga4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24300 Itga4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itga4 NCBI NCBI:3676
Macaca fascicularis Itga4 NCBI NCBI:102128433
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