1. Gene
  2. Itga7 - integrin alpha 7 Gene

Itga7 - integrin alpha 7 Gene

种属: Mus musculus

同用名: [a]7; alpha7

基因 ID: 16404 | 基因类型: protein coding

关于 Itga7

功能概要

This gene encodes a member of the Integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and Other cells. The encoded transmembrane protein is the alpha subunit that forms a noncovalent heterodimer with the beta subunit to form the functional Integrin receptor that binds to laminin. Mice lacking the encoded protein exhibit symptoms of progressive muscular dystrophy, impaired axonal regeneration and cerebral vascular defects. [provided by RefSeq, Aug 2016]

Itga7 基因产物(5)

mRNA Protein Name
NM_001330160.2 NP_001317089.1 integrin alpha-7 isoform 2 precursor
NM_001406285.1 NP_001393214.1 integrin alpha-7 isoform 3
NM_001406286.1 NP_001393215.1 integrin alpha-7 isoform 4
NM_001406287.1 NP_001393216.1 integrin alpha-7 isoform 5
NM_008398.3 NP_032424.2 integrin alpha-7 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to laminin binding IDA
IDA: 通过直接分析推断
1839357 MGI
contributes to laminin binding IMP
IMP: 通过突变表型推断
9004048 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17403664 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blood vessel morphogenesis IMP
IMP: 通过突变表型推断
16003770 MGI
acts upstream of or within cell adhesion IMP
IMP: 通过突变表型推断
9004048 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
9004048 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19796622 MGI
part of integrin alpha7-beta1 complex IDA
IDA: 通过直接分析推断
18611855 MGI
part of integrin alpha7-beta1 complex IPI
IPI: 通过物理相互作用推断
1839357 MGI
located in muscle tendon junction IDA
IDA: 通过直接分析推断
18611855 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
18611855 MGI
located in sarcolemma IDA
IDA: 通过直接分析推断
18611855 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

integrin alpha-7

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itga7 NCBI NCBI:3679