2. Gene
  3. Ncf1 - neutrophil cytosolic factor 1 Gene

Ncf1 - neutrophil cytosolic factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NOXO2; Ncf-1; NCF-47K; p47phox; p47-phox; p47

基因 ID: 17969 | 基因类型: protein coding

关于 Ncf1

功能概要

Enables superoxide-generating NADPH Oxidase activator activity. Acts upstream of or within several processes, including cellular defense response; hydrogen peroxide biosynthetic process; and neutrophil-mediated killing of symbiont cell. Located in cytoplasm and membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system; integumental system; and sensory organ. Used to study chronic granulomatous disease. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncf1 基因产物(2)

mRNA Protein Name
NM_001286037.1 NP_001272966.1 neutrophil cytosol factor 1 isoform a
NM_010876.4 NP_035006.3 neutrophil cytosol factor 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9490028 MGI
enables superoxide-generating NADPH oxidase activator activity IDA
IDA: 通过直接分析推断
8119734 MGI
enables superoxide-generating NADPH oxidase activator activity IMP
IMP: 通过突变表型推断
10987289 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular defense response IMP
IMP: 通过突变表型推断
7650482 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
11907569 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
9116268 MGI
acts upstream of or within defense response to fungus IMP
IMP: 通过突变表型推断
10714686 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: 通过突变表型推断
10987289 MGI
acts upstream of or within hydrogen peroxide biosynthetic process IMP
IMP: 通过突变表型推断
15258578 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
11867678 MGI
acts upstream of or within leukocyte mediated cytotoxicity IMP
IMP: 通过突变表型推断
17526748 MGI
acts upstream of or within leukotriene metabolic process IMP
IMP: 通过突变表型推断
11867678 MGI
acts upstream of or within neutrophil-mediated killing of fungus IMP
IMP: 通过突变表型推断
11907569 MGI
acts upstream of or within neutrophil-mediated killing of gram-positive bacterium IMP
IMP: 通过突变表型推断
11907569 MGI
acts upstream of or within respiratory burst IMP
IMP: 通过突变表型推断
15626477 MGI
acts upstream of or within respiratory burst involved in defense response IMP
IMP: 通过突变表型推断
10714686 MGI
acts upstream of or within response to bacterium IMP
IMP: 通过突变表型推断
10678931 MGI
acts upstream of or within response to yeast IMP
IMP: 通过突变表型推断
10714686 MGI
acts upstream of or within superoxide anion generation IMP
IMP: 通过突变表型推断
10725280 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11156938 MGI
located in membrane IDA
IDA: 通过直接分析推断
26021615 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neutrophil cytosol factor 1

47 kDa neutrophil oxidase factor

NADPH oxidase subunit (47 kD)

NADPH oxidase subunit (47kDa)

neutrophil NADPH oxidase factor 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09077 NCF1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20305 Ncf1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26813 Ncf1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ncf1 NCBI NCBI:653361
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