2. Gene
  3. DUSP2 - dual specificity phosphatase 2 Gene

DUSP2 - dual specificity phosphatase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双特异性磷酸酶 2

种属: Homo sapiens

同用名: PAC1; PAC-1

基因 ID: 1844 | 基因类型: protein coding

关于 DUSP2

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,143,169-96,145,440 (from NCBI)

This gene has 2 transcripts (splice variants), 169 orthologues and 30 paralogues. Biased expression in bone marrow (RPKM 49.4), lymph node (RPKM 22.5) and 9 other tissues.

功能概要

该基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。它们负向调节与细胞增殖和分化相关的丝裂原活化蛋白 (MAP) 激酶超家族成员 (MAPK/ERK、SAPK/JNK、p38) 。双特异性磷酸酶家族的不同成员对各种 MAP 激酶表现出不同的底物特异性、不同的组织分布和亚细胞定位，以及细胞外刺激表达的不同诱导模式。该基因产物使 ERK1 和 ERK2 失活，主要在造血组织中表达，并位于细胞核中。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

DUSP2 基因产物(1)

mRNA Protein Name
NM_004418.4 NP_004409.1 dual specificity protein phosphatase 2

DUSP2 蛋白结构

Rhodanese

Rhodanese: Rhodanese-like domain (18 - 136)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (180 - 310)

  • 0
  • 100
  • 200
  • 314 a.a.
蛋白主名 其他名称

dual specificity protein phosphatase 2

dual specificity protein phosphatase PAC-1

关联疾病

疾病名称 别名
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15486 Salubrinal 99.58% 否
HY-RS04060 DUSP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19430 Dusp2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25921 Dusp2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DUSP2 RGD RGD:1305804
Macaca mulatta DUSP2 VGNC VGNC:106150
Canis familiaris DUSP2 VGNC VGNC:40132
Bos taurus DUSP2 VGNC VGNC:28255
Mus musculus DUSP2 MGD MGI:101911
Felis catus DUSP2 VGNC VGNC:61666
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