2. Gene
  3. Med1 - mediator complex subunit 1 Gene

Med1 - mediator complex subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PBP; Pparbp; TRIP-2; CRSP210; DRIP205; TRAP220; l11Jus15

基因 ID: 19014 | 基因类型: protein coding

关于 Med1

功能概要

Enables several functions, including promoter-specific chromatin binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cellular response to hepatocyte growth factor stimulus; and regulation of signal transduction. Located in nucleus. Part of mediator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Used to study congestive heart failure and dilated cardiomyopathy. Orthologous to human MED1 (mediator complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Med1 基因产物(5)

mRNA Protein Name
NM_001080118.1 NP_001073587.1 mediator of RNA polymerase II transcription subunit 1 isoform 3
NM_001361950.1 NP_001348879.1 mediator of RNA polymerase II transcription subunit 1 isoform 4
NM_001361951.1 NP_001348880.1 mediator of RNA polymerase II transcription subunit 1 isoform 5
NM_013634.2 NP_038662.2 mediator of RNA polymerase II transcription subunit 1 isoform 1
NM_134027.2 NP_598788.2 mediator of RNA polymerase II transcription subunit 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15681609 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
11724781 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
12446761 MGI
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
9325263 MGI
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
22323595 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9325263 MGI
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15340084 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
9325263 MGI
enables transcription corepressor activity IMP
IMP: 通过突变表型推断
16723356 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of G0 to G1 transition IMP
IMP: 通过突变表型推断
17438330 MGI
involved in angiogenesis IMP
IMP: 通过突变表型推断
11724781 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
10747854 MGI
acts upstream of or within animal organ regeneration IMP
IMP: 通过突变表型推断
17438330 MGI
acts upstream of or within brain development IMP
IMP: 通过突变表型推断
10882104 MGI
acts upstream of or within camera-type eye development IMP
IMP: 通过突变表型推断
14500757 MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus IMP
IMP: 通过突变表型推断
17438330 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: 通过突变表型推断
14500757 MGI
acts upstream of or within embryonic hemopoiesis IMP
IMP: 通过突变表型推断
14500757 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: 通过突变表型推断
14500757 MGI
acts upstream of or within embryonic placenta development IMP
IMP: 通过突变表型推断
14500757 MGI
acts upstream of or within enucleate erythrocyte development IMP
IMP: 通过突变表型推断
21098667 MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation IMP
IMP: 通过突变表型推断
15647257 MGI
acts upstream of or within erythrocyte development IMP
IMP: 通过突变表型推断
17132730 MGI
involved in erythrocyte development IMP
IMP: 通过突变表型推断
11724781 MGI
acts upstream of or within fat cell differentiation IMP
IMP: 通过突变表型推断
12037571 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
10882104 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
16324150 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
14500757 MGI
acts upstream of or within lactation IMP
IMP: 通过突变表型推断
15647257 MGI
involved in lens development in camera-type eye IMP
IMP: 通过突变表型推断
11724781 MGI
acts upstream of or within liver development IMP
IMP: 通过突变表型推断
14500757 MGI
involved in mRNA transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16723356 MGI
acts upstream of or within mammary gland branching involved in pregnancy IMP
IMP: 通过突变表型推断
15647257 MGI
acts upstream of or within mammary gland branching involved in thelarche IMP
IMP: 通过突变表型推断
15647257 MGI
acts upstream of or within mammary gland epithelial cell proliferation IMP
IMP: 通过突变表型推断
15843544 MGI
involved in megakaryocyte development IMP
IMP: 通过突变表型推断
11724781 MGI
acts upstream of or within monocyte differentiation IMP
IMP: 通过突变表型推断
16324150 MGI
acts upstream of or within multicellular organism development IMP
IMP: 通过突变表型推断
10882104 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16723356 MGI
involved in negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
16723356 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16723356 MGI
acts upstream of or within peroxisome proliferator activated receptor signaling pathway IMP
IMP: 通过突变表型推断
15150259 MGI
acts upstream of or within positive regulation of G0 to G1 transition IMP
IMP: 通过突变表型推断
17438330 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
10882104 MGI
acts upstream of or within positive regulation of hepatocyte proliferation IMP
IMP: 通过突变表型推断
17438330 MGI
acts upstream of or within positive regulation of intracellular estrogen receptor signaling pathway IMP
IMP: 通过突变表型推断
20351249 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11724781 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17827210 MGI
acts upstream of or within positive regulation of type II interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
18339625 MGI
acts upstream of or within protein import into nucleus IMP
IMP: 通过突变表型推断
16828057 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9325263 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
10882104 MGI
acts upstream of or within regulation of vitamin D receptor signaling pathway IMP
IMP: 通过突变表型推断
16324150 MGI
involved in retinal pigment epithelium development IMP
IMP: 通过突变表型推断
11724781 MGI
acts upstream of or within thyroid hormone generation IMP
IMP: 通过突变表型推断
10882104 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: 通过突变表型推断
11724781 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mediator complex IDA
IDA: 通过直接分析推断
12093747 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15150259 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 1

PPAR-binding protein

Ppar binding protein

TR-interacting protein 2

peroxisome proliferator-activated receptor-binding protein

thyroid hormone receptor-associated protein complex 220 kDa component

thyroid receptor-interacting protein 2

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08184 MBD4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08278 MED1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18247 Med1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19616 Mbd4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22462 Cwc15 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24727 Med1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Med1 NCBI NCBI:5469
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